{"id":"W2033437534","doi":"10.1042/bj20140153","title":"Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation","year":2014,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Ontario Ministry of Economic Development and Innovation; Ministero dello Sviluppo Economico; Diamond Light Source; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Degron; Cullin; Cell biology; Biology; Ubiquitin ligase; Ubiquitin; Pseudohypoaldosteronism; Autophosphorylation; Kinase; Biochemistry; Protein kinase A; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059708,0.0002741118,0.0001687753,0.00008111115,0.0002873517,0.0002012782,0.000415701,0.0002216944,0.001169674],"category_scores_gemma":[0.0002012239,0.0001255935,0.0001993418,0.0001753301,0.0001618779,0.0001590864,0.0002316383,0.0005423227,0.0002128029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007790524,"about_ca_system_score_gemma":0.0003767532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005248985,"about_ca_topic_score_gemma":0.004954033,"domain_scores_codex":[0.9999213,0.00001071368,0.000004499008,0.0000120782,0.00002884946,0.00002250444],"domain_scores_gemma":[0.9999212,0.00001058862,0.00002029755,0.000004817712,0.00001323385,0.00002991059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004604606,0.0001583206,0.003589746,0.00008993776,0.00004338431,0.000668729,0.00007885502,0.003173807,0.9865071,0.0007423908,0.000515261,0.003972104],"study_design_scores_gemma":[0.0002030879,0.0004251176,0.07521679,0.00003154673,0.00009696701,0.002372407,0.0003421716,0.04888832,0.8554218,0.0008872225,0.01604816,0.0000663821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997187,0.0006526947,0.0009019315,0.0001459221,0.00001600038,0.000006927467,0.000231587,0.00002413666,0.0008338253],"genre_scores_gemma":[0.9950023,0.0004246999,0.00190829,0.00009762867,0.000008866758,0.000007807594,0.001238746,0.00001159668,0.001300035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005248985,"threshold_uncertainty_score":0.01043689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006803378267791127,"score_gpt":0.2445283276494057,"score_spread":0.2377249493816146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}