{"id":"W2033437534","doi":"10.1042/bj20140153","title":"Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation","year":2014,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Ontario Ministry of Economic Development and Innovation; Ministero dello Sviluppo Economico; Diamond Light Source; Wellcome Trust; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Degron; Cullin; Cell biology; Biology; Ubiquitin ligase; Ubiquitin; Pseudohypoaldosteronism; Autophosphorylation; Kinase; Biochemistry; Protein kinase A; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002515526,0.0001467328,0.0001531108,0.00004945277,0.00006044586,0.00003428402,0.0002156507,0.000240164,0.00001886437],"category_scores_gemma":[0.0002988843,0.0001053487,0.00009954831,0.0001278161,0.0001639686,0.00000965645,0.0001821341,0.0003111981,3.991146e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008880095,"about_ca_system_score_gemma":0.00004183482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007126549,"about_ca_topic_score_gemma":0.000001212938,"domain_scores_codex":[0.9987629,0.0001096058,0.0003923826,0.0002721805,0.000241094,0.0002218211],"domain_scores_gemma":[0.9993166,0.00001241272,0.0002022383,0.0002372397,0.0001126016,0.0001189576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001370208,0.00004806062,0.007071981,0.00003292127,0.00003706204,8.988912e-7,0.00001629551,0.000001385526,0.9917508,0.00005428063,0.0001388428,0.0007104266],"study_design_scores_gemma":[0.0006593707,0.00009209563,0.0305618,0.00005965715,0.00004316095,0.0001538212,0.000007576352,0.0003239437,0.9667407,0.0001863966,0.001046302,0.0001251225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986088,0.0006078628,0.0001400111,0.0003434922,0.00010772,0.0001351695,0.00001016479,0.000003842964,0.0000429736],"genre_scores_gemma":[0.9991853,0.0001326575,0.0001515835,0.00009211573,0.0002865659,0.000004936951,0.00007395002,0.00001490734,0.00005804852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02501007,"threshold_uncertainty_score":0.4295994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006803378267791127,"score_gpt":0.2445283276494057,"score_spread":0.2377249493816146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}