{"id":"W2033461907","doi":"10.1016/j.cell.2014.11.048","title":"Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":564,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakehead University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Austrian Science Fund; American Heart Association","keywords":"Biology; Cystathionine beta synthase; Longevity; Hydrogen sulfide; Cystathionine gamma-lyase; Biochemistry; Enzyme; Genetics; Amino acid; Sulfur; Cell biology; Methionine; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001025605,0.000272254,0.0002454111,0.0001957182,0.0001587854,0.0003519971,0.0001929181,0.000310638,0.00118405],"category_scores_gemma":[0.0001209355,0.0001524725,0.0001454796,0.0001402882,0.000325767,0.0002356848,0.0002445584,0.0003236894,0.0001504781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003921943,"about_ca_system_score_gemma":0.0003752194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001035409,"about_ca_topic_score_gemma":0.001905753,"domain_scores_codex":[0.9999382,0.000009383283,0.000004639488,0.0000176004,0.00001825627,0.00001186683],"domain_scores_gemma":[0.9998682,0.00002184324,0.00003594972,0.000019877,0.0000168212,0.00003726874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003497702,0.00001339543,0.0003900405,0.0000222667,0.00000689004,0.00004839658,0.000007112049,0.00004585011,0.9976296,0.000399201,0.0000632947,0.00102402],"study_design_scores_gemma":[0.00004452089,0.0001985777,0.01370235,0.000009222721,0.00003433562,0.0002054303,0.00004630274,0.0009260832,0.9804079,0.0007348803,0.003680109,0.00001030103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900364,0.002438854,0.004788452,0.000461112,0.00009387054,0.00001462017,0.000589444,0.0001780643,0.001399226],"genre_scores_gemma":[0.9953923,0.0008704378,0.001457307,0.00005741658,0.00001299085,0.00001350159,0.0003420134,0.0000299115,0.001824203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118405,"threshold_uncertainty_score":0.003961027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172644993540113,"score_gpt":0.2156591743796026,"score_spread":0.1983946750255912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}