{"id":"W2033461907","doi":"10.1016/j.cell.2014.11.048","title":"Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits","year":2014,"lang":"en","type":"article","venue":"Cell","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":564,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakehead University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Austrian Science Fund; American Heart Association","keywords":"Biology; Cystathionine beta synthase; Longevity; Hydrogen sulfide; Cystathionine gamma-lyase; Biochemistry; Enzyme; Genetics; Amino acid; Sulfur; Cell biology; Methionine; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001428984,0.0001416464,0.0001097086,0.00003298679,0.0001433711,0.00001973887,0.0001371685,0.0001356725,0.00000949925],"category_scores_gemma":[0.00004238148,0.0001515586,0.0000958284,0.00004475271,0.00003555883,0.000003507025,0.00004981512,0.00005329152,0.00002344696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001059619,"about_ca_system_score_gemma":0.00002975934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003237758,"about_ca_topic_score_gemma":0.00001654283,"domain_scores_codex":[0.9990493,0.00003105217,0.0001625305,0.000413044,0.0001019068,0.0002421387],"domain_scores_gemma":[0.9993837,0.000006576456,0.00007596115,0.0003751331,0.00009088109,0.00006771741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003621945,0.00007461313,0.0002875321,0.00003912493,0.00001929937,2.436836e-7,0.0001630027,0.001364604,0.9924281,0.0000136031,0.003966175,0.001607467],"study_design_scores_gemma":[0.0003174272,0.0002833043,0.0003155011,0.000003296178,0.00004988072,0.000009081932,0.00002140207,0.000306172,0.9668263,0.0002424065,0.03144558,0.0001796501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905828,0.000982415,0.006509694,0.0002060484,0.0006528973,0.000313643,0.00002065255,0.00002366363,0.0007082039],"genre_scores_gemma":[0.9952399,0.0005414361,0.00116078,0.0002401523,0.001291846,0.00002713436,0.0002292851,0.00003446891,0.00123505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0274794,"threshold_uncertainty_score":0.6180382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172644993540113,"score_gpt":0.2156591743796026,"score_spread":0.1983946750255912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}