{"id":"W2033489858","doi":"10.1016/j.bbadis.2014.12.023","title":"γ-Glutamyl cysteine and γ-glutamyl valine inhibit TNF-α signaling in intestinal epithelial cells and reduce inflammation in a mouse model of colitis via allosteric activation of the calcium-sensing receptor","year":2015,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":180,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Networks of Centres of Excellence of Canada; Advanced Foods and Materials Network","keywords":"Calcium-sensing receptor; Inflammation; Inflammatory bowel disease; Colitis; Chemistry; Allosteric regulation; Receptor; Chemokine; Tumor necrosis factor alpha; In vivo; Intestinal mucosa; Pharmacology; Endocrinology; Internal medicine; Calcium; Calcium metabolism; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003153876,0.0002682302,0.000384174,0.0001734691,0.00002503289,0.00001353134,0.0002193704,0.0001616891,6.995596e-7],"category_scores_gemma":[0.0003792291,0.0002491918,0.0001107065,0.0002646375,0.0003747265,0.00002266974,0.0003224185,0.0001395595,2.037219e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004217029,"about_ca_system_score_gemma":0.0002375867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000102901,"about_ca_topic_score_gemma":0.00001021804,"domain_scores_codex":[0.9980592,0.000358949,0.0006446858,0.0004613219,0.0002421218,0.0002337565],"domain_scores_gemma":[0.9986697,0.00005438268,0.0004784688,0.0004383949,0.0002187126,0.0001403811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001371688,0.0001720912,0.00009618164,0.0001383326,0.00004097704,0.00000131074,0.0002412435,0.001164209,0.9963212,0.00003197381,0.000005990967,0.0004147924],"study_design_scores_gemma":[0.001319895,0.0003138359,0.0008939931,0.0001914648,0.00004975372,0.000002636439,0.00007457058,0.006213294,0.9903659,0.0003427617,0.000002530554,0.0002294047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978195,0.00007308373,0.001001416,0.0004064571,0.00004451741,0.0004607456,0.0001763146,0.000007015938,0.00001091104],"genre_scores_gemma":[0.9968651,0.00003677879,0.002800336,0.00007946395,0.00004844884,0.00001401298,0.0001142681,0.00003465957,0.000006964712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00595535,"threshold_uncertainty_score":0.999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914033688592798,"score_gpt":0.2485943360174791,"score_spread":0.2294539991315511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}