{"id":"W2033539268","doi":"10.1038/ncprheum1025","title":"Is spleen tyrosine kinase inhibition an effective therapy for patients with RA?","year":2009,"lang":"en","type":"review","venue":"Nature Reviews Rheumatology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Syk; Medicine; Rheumatoid arthritis; Tyrosine kinase; Immune system; Immunology; Signal transduction; Adverse effect; Receptor; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004870547,0.0009662377,0.00476903,0.0003137691,0.0002384136,0.00002380452,0.0003787793,0.002804651,0.0004629649],"category_scores_gemma":[0.0001130738,0.0006019121,0.0009282208,0.0003452164,0.0002058799,0.0001116196,0.00004705728,0.001569812,0.0003262104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000110931,"about_ca_system_score_gemma":0.0001159926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001495263,"about_ca_topic_score_gemma":0.00002192421,"domain_scores_codex":[0.9960884,0.001033356,0.00111862,0.001065093,0.00006094085,0.0006336303],"domain_scores_gemma":[0.9972916,0.0003481497,0.001220404,0.0008189442,0.0002575778,0.00006331634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002054591,0.0005127615,0.0000281615,0.009152474,0.0003311169,0.000002876287,0.00004392742,1.154454e-8,0.000003005529,0.000477649,0.01944679,0.9697958],"study_design_scores_gemma":[0.002699541,0.001741475,0.00003692631,0.01000317,0.0006215192,0.0001375726,0.000001384086,1.393109e-7,0.00001492292,0.00003758937,0.9840717,0.0006340717],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001032328,0.9904079,0.00005851043,0.00005162563,0.0009625056,0.007783286,0.0004314226,0.00007225631,0.0001292241],"genre_scores_gemma":[0.00007252795,0.9890937,0.0002045623,0.0003998991,0.00004441046,0.001054314,0.008528016,0.00009475957,0.0005077862],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9691617,"threshold_uncertainty_score":0.9996432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335534159149387,"score_gpt":0.2956843199244013,"score_spread":0.2823289783329074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}