{"id":"W2033556029","doi":"10.1073/pnas.0611662104","title":"Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Terry Fox Foundation","keywords":"Hypoxia (environmental); Tumor microenvironment; Tumor hypoxia; Cancer research; Cytotoxic T cell; Metabolism; Cytotoxicity; Biology; Pharmacology; Chemistry; Tumor cells; Oxygen; Biochemistry; Medicine; Internal medicine; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001384637,0.00008447299,0.0001791665,0.0001125815,0.00005469841,0.000006187137,0.0003430249,0.00007605719,0.000002858588],"category_scores_gemma":[0.0002809858,0.00006376119,0.00005116949,0.0003736868,0.0005374782,0.00001633772,0.00007730004,0.00008246413,5.663786e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006965997,"about_ca_system_score_gemma":0.00004536062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002050065,"about_ca_topic_score_gemma":0.000001643405,"domain_scores_codex":[0.9988897,0.000004272833,0.0003244073,0.0002154147,0.0004013693,0.0001648568],"domain_scores_gemma":[0.9994518,0.00002009304,0.0003431886,0.000009191564,0.0001443767,0.00003139386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002496492,0.00002190074,0.003399776,0.00002559795,0.000008297425,1.560126e-9,0.0001427372,0.00001197318,0.9935537,0.001583407,0.0001313541,0.001096286],"study_design_scores_gemma":[0.0001861749,0.00002759191,0.09982422,0.00002904808,0.000004255124,0.000003044917,0.0001348783,0.00002366522,0.8963394,0.001991591,0.001373669,0.000062509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959794,0.002527548,0.000002575165,0.0004072103,0.00003075018,0.0001165626,0.000008281708,0.000001832077,0.000925848],"genre_scores_gemma":[0.9975511,0.000786106,0.001113692,0.0002281731,0.0002262972,0.000003716681,2.199223e-7,0.000004445144,0.00008624093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09721435,"threshold_uncertainty_score":0.2600106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01404947364534916,"score_gpt":0.295141867219209,"score_spread":0.2810923935738599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}