{"id":"W2033573667","doi":"10.1074/jbc.m409189200","title":"Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Endocrinology; Lipotoxicity; Pancreatic islets; Islet; Biology; Mitochondrion; Hyperpolarization (physics); Uncoupling protein; Mitochondrial ROS; L-Glucose; Insulin; Chemistry; Biochemistry; Insulin resistance; Oxidative stress; Adipose tissue; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946219,0.0008225486,0.0003508984,0.0004613276,0.0001543925,0.0004595328,0.0003404164,0.0002998021,0.002206073],"category_scores_gemma":[0.0002040978,0.0003780574,0.0003779812,0.0002222824,0.0003452261,0.0003411425,0.0004377496,0.0008656263,0.0006443863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002940031,"about_ca_system_score_gemma":0.0001601257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004627152,"about_ca_topic_score_gemma":0.0005306777,"domain_scores_codex":[0.9997117,0.00003306194,0.0000398038,0.00007917039,0.00009689222,0.00003940284],"domain_scores_gemma":[0.9996641,0.00003431112,0.0001056298,0.0000548172,0.00004379808,0.00009731256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001228672,0.0000117856,0.0001809635,0.00001725069,0.000005827222,0.00005800169,0.000005922099,0.00001128138,0.9991591,0.00002114972,0.00001971145,0.0003860583],"study_design_scores_gemma":[0.00004814727,0.0002193837,0.02410256,0.00001833045,0.00003268089,0.0008949459,0.00003821362,0.000540318,0.9717239,0.000084482,0.002286879,0.00001007015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916893,0.002056699,0.00338703,0.0001480918,0.00007513283,0.00003634215,0.0009308113,0.0001979662,0.001478545],"genre_scores_gemma":[0.9884235,0.002045506,0.00294515,0.000148622,0.00002726776,0.0001274006,0.001676113,0.0001537024,0.004452779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002206073,"threshold_uncertainty_score":0.007380068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03447226665772619,"score_gpt":0.2737859795648768,"score_spread":0.2393137129071506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}