{"id":"W2033585878","doi":"10.1074/jbc.m802064200","title":"Displacement of the Occluding Loop by the Parasite Protein, Chagasin, Results in Efficient Inhibition of Human Cathepsin B","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"Vetenskapsrådet; Lunds Universitet; Crafoordska Stiftelsen; Cancerfonden","keywords":"Cathepsin O; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsin A; Cathepsin; Papain; Cathepsin E; Exopeptidase; Active site; Cathepsin C; Chemistry; Biochemistry; Cysteine protease; Cysteine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236221,0.000208245,0.0002758963,0.00006872243,0.0001134546,0.0002802486,0.0003060361,0.0002322422,0.0005259532],"category_scores_gemma":[0.0002577085,0.000171778,0.0001458769,0.0001095159,0.0002362736,0.0001674538,0.0001701584,0.0003887541,0.0001256645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000402022,"about_ca_system_score_gemma":0.0002688002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001573154,"about_ca_topic_score_gemma":0.001925415,"domain_scores_codex":[0.9998838,0.00001625701,0.0000106883,0.000021977,0.00003163827,0.000035646],"domain_scores_gemma":[0.9999245,0.00001793624,0.00002479184,0.000006027481,0.000004676499,0.00002200711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003574725,0.00007952,0.0008509178,0.0000656831,0.00002147097,0.0001425013,0.00004064177,0.0007488395,0.9962048,0.0002274412,0.00007660941,0.001184045],"study_design_scores_gemma":[0.0001237592,0.0006851685,0.009903985,0.00002123207,0.0000465825,0.0007895561,0.00006609769,0.007261378,0.9773826,0.00009527294,0.00360901,0.00001528404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992419,0.0004025416,0.0001707227,0.00002056449,0.000004493508,0.000002073704,0.00003131054,0.00000697515,0.0001193536],"genre_scores_gemma":[0.9985097,0.0002660854,0.0006395323,0.00002517398,0.000002713671,0.000004541359,0.0001958844,0.000005378021,0.0003509806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001573154,"threshold_uncertainty_score":0.003127992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05440369871796242,"score_gpt":0.3215167961084726,"score_spread":0.2671130973905102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}