{"id":"W2033585878","doi":"10.1074/jbc.m802064200","title":"Displacement of the Occluding Loop by the Parasite Protein, Chagasin, Results in Efficient Inhibition of Human Cathepsin B","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada","funders":"Vetenskapsrådet; Lunds Universitet; Crafoordska Stiftelsen; Cancerfonden","keywords":"Cathepsin O; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsin A; Cathepsin; Papain; Cathepsin E; Exopeptidase; Active site; Cathepsin C; Chemistry; Biochemistry; Cysteine protease; Cysteine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001790014,0.00007805361,0.0002187632,0.00002201823,0.00008203308,0.000003303734,0.0001598672,0.00008048822,0.00003682798],"category_scores_gemma":[0.0005640229,0.00003515558,0.0001269999,0.0002155631,0.0003670808,0.00001432881,0.00006100977,0.0003423157,6.227657e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008560713,"about_ca_system_score_gemma":0.00007330452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009905752,"about_ca_topic_score_gemma":6.842392e-7,"domain_scores_codex":[0.998794,0.00005773866,0.0005800583,0.00009817741,0.0003170475,0.0001530421],"domain_scores_gemma":[0.9990485,0.00007416938,0.0004316159,0.0002091926,0.0001676281,0.00006893645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002888446,0.0004086135,0.005489824,0.00003418478,0.00001506577,0.000008011913,0.00009810561,0.000009140756,0.9927601,0.00001216493,0.0007937634,0.00008219918],"study_design_scores_gemma":[0.001011951,0.0002720981,0.1673006,0.0001931504,0.000006995745,0.0001460312,0.0001415629,0.00001021696,0.8306268,0.00002456579,0.0002330892,0.00003286174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966298,0.0002985423,0.00001545668,0.002024481,0.000009217374,0.0002274755,0.0000322089,0.000002299006,0.0007605669],"genre_scores_gemma":[0.999544,0.00007307014,0.00003170859,0.00002948583,0.00005572636,0.000006293585,0.000009198188,0.0000031278,0.0002473913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1621332,"threshold_uncertainty_score":0.1487211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05440369871796242,"score_gpt":0.3215167961084726,"score_spread":0.2671130973905102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}