{"id":"W2033604768","doi":"10.1016/j.bbmt.2013.08.014","title":"Effect of Weight and Maturation on Busulfan Clearance in Infants and Small Children Undergoing Hematopoietic Cell Transplantation","year":2013,"lang":"en","type":"article","venue":"Biology of Blood and Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Otsuka Pharmaceutical Development and Commercialization","keywords":"Busulfan; Medicine; Dosing; Pharmacokinetics; Therapeutic drug monitoring; Hematopoietic stem cell transplantation; Transplantation; Hematopoietic cell; Population; Body surface area; Haematopoiesis; Pediatrics; Pharmacology; Internal medicine; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001275115,0.0002660547,0.0003898773,0.0002049232,0.0001082831,0.0004902381,0.0001816511,0.0002046528,0.0003559386],"category_scores_gemma":[0.007464313,0.000119908,0.0003580445,0.0001880287,0.0002925746,0.0002412891,0.0003789853,0.0004296135,0.0001031754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006465304,"about_ca_system_score_gemma":0.000546397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00276118,"about_ca_topic_score_gemma":0.00183846,"domain_scores_codex":[0.9994596,0.0002855037,0.00003155832,0.0000500453,0.0001123751,0.00006098942],"domain_scores_gemma":[0.9978167,0.001067549,0.0007360964,0.00008963753,0.0001081802,0.0001819365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006118441,0.0001598878,0.9093623,0.00004799608,0.0002108392,0.001160735,0.0002796882,0.01733096,0.01205684,0.0003811628,0.0003325195,0.05255865],"study_design_scores_gemma":[0.0001216639,0.006035324,0.9206841,0.00003997287,0.0003107045,0.002857256,0.0003525791,0.04962317,0.01789219,0.0004131436,0.001634741,0.00003520083],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986849,0.0004182254,0.0006349232,0.00004303473,0.000003355167,0.000004769018,0.00002980281,0.000009988575,0.000171085],"genre_scores_gemma":[0.9993238,0.0002190646,0.0003246457,0.00001154175,0.000002548129,0.000004270099,0.00005417386,0.000006232136,0.00005376217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00276118,"threshold_uncertainty_score":0.00674355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004711160429878194,"score_gpt":0.2171360366091746,"score_spread":0.2124248761792964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}