{"id":"W2033650657","doi":"10.1002/cbic.201100121","title":"Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Homoserine; Antimicrobial; Biochemistry; Kinase; Chemistry; Biology; Microbiology; Computational biology; Quorum sensing; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002895457,0.0006551135,0.0006305237,0.0006002892,0.0001986108,0.0004996863,0.0004916443,0.000387708,0.001619417],"category_scores_gemma":[0.0002348625,0.0002613109,0.0004377296,0.000313522,0.0001742733,0.000357846,0.0002425548,0.0008304893,0.0005734321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000367886,"about_ca_system_score_gemma":0.0003356252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004068643,"about_ca_topic_score_gemma":0.001133927,"domain_scores_codex":[0.9998548,0.00001679403,0.00001344114,0.00002329944,0.00005602689,0.00003563093],"domain_scores_gemma":[0.9998691,0.00001929838,0.00002795906,0.00001050842,0.00003087555,0.00004222288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005486339,0.0007692343,0.0005156075,0.0002136334,0.0000727414,0.0002914441,0.000041864,0.001405041,0.9606017,0.0004035168,0.0005565216,0.03458008],"study_design_scores_gemma":[0.000695738,0.00549494,0.003163006,0.0000410879,0.0001903184,0.001524709,0.00003351789,0.0027843,0.95968,0.0001677611,0.02619058,0.00003409745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935025,0.0362462,0.01676723,0.0005380081,0.0001375732,0.0009074684,0.00173633,0.0002940681,0.008348136],"genre_scores_gemma":[0.9470655,0.02403045,0.01581438,0.0003888878,0.00007824753,0.0004087802,0.004110631,0.00007453832,0.008028561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619417,"threshold_uncertainty_score":0.005417526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02488373131977512,"score_gpt":0.2500191152573888,"score_spread":0.2251353839376137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}