{"id":"W2033650657","doi":"10.1002/cbic.201100121","title":"Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase","year":2011,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Homoserine; Antimicrobial; Biochemistry; Kinase; Chemistry; Biology; Microbiology; Computational biology; Quorum sensing; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009837138,0.00006595435,0.0001722746,0.00003575815,0.00001192058,0.000002018456,0.00003314912,0.00005877064,0.00007719137],"category_scores_gemma":[0.00006324617,0.00006135921,0.00004075254,0.0001135811,0.00008397981,0.00006139681,0.00001951821,0.00004409993,0.00000296158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001087357,"about_ca_system_score_gemma":0.0000480103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002383505,"about_ca_topic_score_gemma":0.000002493658,"domain_scores_codex":[0.9994195,0.00000578674,0.0002564063,0.0001422374,0.0001048512,0.00007129408],"domain_scores_gemma":[0.9994807,0.000005500906,0.0001320573,0.0002088854,0.0001047855,0.00006813254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001547836,0.0001033223,0.0981793,0.0002381722,0.0000117755,0.000001255078,0.000502416,1.274663e-9,0.8981264,0.0001043203,0.00005107685,0.002527132],"study_design_scores_gemma":[0.0002185126,0.00004781648,0.4248523,0.00004049925,0.00002173546,0.000001572194,0.00006027782,0.000002835436,0.5746684,0.0000310935,0.0000274485,0.00002745987],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998891,0.0001162854,0.0001269957,0.00003832726,0.00004116799,0.0001330914,0.000006684644,0.00001247848,0.0006339901],"genre_scores_gemma":[0.9984204,0.00006234425,0.0001375057,0.00001402324,0.00004396672,0.000001814965,0.00003202423,0.000007294521,0.001280686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.326673,"threshold_uncertainty_score":0.2502156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02488373131977512,"score_gpt":0.2500191152573888,"score_spread":0.2251353839376137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}