{"id":"W2033673797","doi":"10.1074/jbc.m302272200","title":"Cre Induces an Asymmetric DNA Bend in Its Target loxP Site","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Phosphodiester bond; Scissile bond; Base pair; Recombination; Site-specific recombination; Chemistry; DNA; Cre recombinase; Stereochemistry; Active site; RNA; Recombinase; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002853465,0.0003398944,0.0002718496,0.0001698353,0.0001678088,0.0003599545,0.0002689327,0.0004737024,0.003043832],"category_scores_gemma":[0.0002900093,0.000333877,0.0002423391,0.00009952101,0.0003828076,0.0002125205,0.0004088828,0.001309108,0.001166855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002873257,"about_ca_system_score_gemma":0.0002297226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001898863,"about_ca_topic_score_gemma":0.0002728642,"domain_scores_codex":[0.9997143,0.00003944499,0.0000166208,0.00007032439,0.0001028158,0.0000564839],"domain_scores_gemma":[0.9997085,0.00005833661,0.00008845377,0.00004448354,0.00002880769,0.00007145056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003251593,0.000008999327,0.00005532449,0.00001092585,0.000001361681,0.00002278973,0.000004488899,0.00005002204,0.9992954,0.0001270377,0.00001081297,0.0003803274],"study_design_scores_gemma":[0.00001620061,0.0001445761,0.001506542,0.000005129276,0.000003582523,0.000274448,0.0000135555,0.0004806682,0.9957014,0.0001158261,0.001733986,0.000004233221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754287,0.0007643834,0.01865078,0.0001656646,0.00007230128,0.00008382137,0.0002812026,0.0003049984,0.004248023],"genre_scores_gemma":[0.9866825,0.0003442784,0.007243611,0.0001645011,0.00001766977,0.00004299263,0.0005307869,0.00005380649,0.004919754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003043832,"threshold_uncertainty_score":0.01018262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01793706719311271,"score_gpt":0.2534928756343729,"score_spread":0.2355558084412602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}