{"id":"W2033731279","doi":"10.1038/mt.2010.255","title":"Remission of Diabetes by Insulin Gene Therapy Using a Hepatocyte-specific and Glucose-responsive Synthetic Promoter","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Insulin; Internal medicine; Endocrinology; Hepatocyte; Diabetes mellitus; Enhancer; Biology; Response element; Genetic enhancement; Promoter; Gene expression; Gene; In vitro; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000290176,0.000207091,0.0003742905,0.0001165442,0.00005960928,0.0000199372,0.00007188309,0.000150159,0.0002196211],"category_scores_gemma":[0.00009845877,0.0001572115,0.0001013482,0.000169382,0.0001474079,0.00004131754,0.00001826733,0.000197181,0.000005976098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001693367,"about_ca_system_score_gemma":0.00005768797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001053929,"about_ca_topic_score_gemma":9.635723e-8,"domain_scores_codex":[0.9988298,0.0001250564,0.0002562587,0.0003106556,0.000245203,0.0002329922],"domain_scores_gemma":[0.9991028,0.00009698144,0.000106609,0.0004183851,0.0001193695,0.0001558317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006071437,0.0001985742,0.00338712,0.00001533422,0.0000865231,0.000009653077,0.0001946614,6.210263e-7,0.9678143,0.00001719247,0.00006616959,0.02760275],"study_design_scores_gemma":[0.002902435,0.0004981916,0.002508341,0.00007185623,0.0000194562,0.00001395926,0.00002027383,0.0005980614,0.9828271,0.000148062,0.01023491,0.0001573606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833189,0.01527145,0.0002821207,0.0003081925,0.0001125541,0.0005377015,0.000009324997,0.00004378053,0.0001160107],"genre_scores_gemma":[0.9949079,0.001599018,0.002557413,0.0007355848,0.00004530267,0.00002222389,0.00001624523,0.00004606566,0.00007024816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02744539,"threshold_uncertainty_score":0.64109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591336605973273,"score_gpt":0.2502706478957144,"score_spread":0.2343572818359817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}