{"id":"W2033731279","doi":"10.1038/mt.2010.255","title":"Remission of Diabetes by Insulin Gene Therapy Using a Hepatocyte-specific and Glucose-responsive Synthetic Promoter","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Insulin; Internal medicine; Endocrinology; Hepatocyte; Diabetes mellitus; Enhancer; Biology; Response element; Genetic enhancement; Promoter; Gene expression; Gene; In vitro; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002811452,0.0003452412,0.0002751964,0.000249643,0.00007903555,0.0002772493,0.0001855664,0.0001879579,0.0008504879],"category_scores_gemma":[0.0001603642,0.0001140963,0.0002452619,0.000174835,0.0002250045,0.0001596985,0.0001900957,0.0006146348,0.0002794144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002229087,"about_ca_system_score_gemma":0.0003221332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000147796,"about_ca_topic_score_gemma":0.000225463,"domain_scores_codex":[0.9997975,0.00003949502,0.00002043787,0.00003698061,0.000066324,0.00003939585],"domain_scores_gemma":[0.9998868,0.00001979153,0.00004546878,0.00001187156,0.000009685961,0.00002653684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118423,0.00005005074,0.0001342975,0.00003981358,0.000004657021,0.00004104528,0.0000112129,0.0001198441,0.9954436,0.0002894877,0.00004372491,0.003710485],"study_design_scores_gemma":[0.00006648825,0.0007835158,0.0006961072,0.00000984696,0.00002178776,0.0004667743,0.00001617947,0.001538174,0.9917651,0.00008447671,0.004546268,0.000005419608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951173,0.002433845,0.04221402,0.0002683562,0.0001162402,0.0001321578,0.0003853485,0.0003753148,0.002901743],"genre_scores_gemma":[0.9615139,0.001731511,0.03082016,0.0001011911,0.00003797763,0.0001229285,0.0008280692,0.00009056702,0.004753727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008504879,"threshold_uncertainty_score":0.002845228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591336605973273,"score_gpt":0.2502706478957144,"score_spread":0.2343572818359817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}