{"id":"W2033749895","doi":"10.1089/104303400750001426","title":"Treatment of a Lysosomal Storage Disease, Mucopolysaccharidosis VII, with Microencapsulated Recombinant Cells","year":2000,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McMaster University","funders":"Medical Research Council","keywords":"Enzyme replacement therapy; Mucopolysaccharidosis; Lysosomal storage disease; Spleen; Antibody; Glycosaminoglycan; Glucuronidase; Immune system; Molecular biology; Biology; Enzyme; Chemistry; Immunology; Endocrinology; Internal medicine; Medicine; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006086209,0.0003261157,0.0005405936,0.0001807596,0.0001676361,0.00002402386,0.0001763182,0.00007875384,0.005676774],"category_scores_gemma":[0.000001947873,0.000229455,0.0002056069,0.0003585754,0.0001927906,0.00006784282,0.00001217178,0.0001022928,0.00009966987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000208553,"about_ca_system_score_gemma":0.0001789074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004489289,"about_ca_topic_score_gemma":0.00001820378,"domain_scores_codex":[0.998131,0.00009309619,0.0003394089,0.0004759638,0.0004720685,0.0004884591],"domain_scores_gemma":[0.9987217,0.00002047683,0.00009132833,0.0007036052,0.000124712,0.0003381497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007239027,0.00521838,0.0117887,0.00006389999,0.0007162869,0.0009203556,0.00187986,0.00004640909,0.9281703,0.00002406942,0.000468336,0.04346443],"study_design_scores_gemma":[0.0287473,0.01718925,0.1118699,0.0001559611,0.0002915597,0.0001453234,0.0001752585,0.0002419245,0.8293461,0.0001873255,0.0108858,0.0007643464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939596,0.003594874,0.000006780406,0.0002519181,0.00004130937,0.001105651,0.00002654657,0.00008909492,0.0009241939],"genre_scores_gemma":[0.9886445,0.003233024,0.0002115099,0.0001062332,0.00007638977,0.00009471015,0.00007828711,0.00007816206,0.007477162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1000812,"threshold_uncertainty_score":0.9952322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0268769223197645,"score_gpt":0.2854139926065553,"score_spread":0.2585370702867908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}