{"id":"W2033759470","doi":"10.1002/syn.21541","title":"Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2‐(4,5‐Dihydro‐1<i>H</i>‐imidazol‐2‐yl)‐1‐ methyl‐1<i>H</i>‐indole), for the imidazoline<sub>2</sub> binding site","year":2012,"lang":"en","type":"article","venue":"Synapse","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Radioligand; Positron emission tomography; In vivo; Ex vivo; Ligand (biochemistry); Human brain; Chemistry; Radiosynthesis; In vitro; Imidazoline receptor; Binding potential; Neuroscience; Pharmacology; Biophysics; Receptor; Biochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002004874,0.0002483582,0.0002631106,0.0003309802,0.0005618299,0.00008914595,0.0003573784,0.0001293683,0.000006061885],"category_scores_gemma":[0.0007470417,0.0001658536,0.0001082128,0.0008608412,0.0005164686,0.0006223957,0.0003157926,0.0003838436,0.000003229474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003479807,"about_ca_system_score_gemma":0.00009595064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006695345,"about_ca_topic_score_gemma":0.000002231593,"domain_scores_codex":[0.9968297,0.0008163428,0.0004107264,0.0005482524,0.0007686973,0.0006262872],"domain_scores_gemma":[0.9985562,0.0006258042,0.0002629982,0.0002904411,0.0001113321,0.0001532367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004284627,0.00011702,0.001549612,0.00003387594,0.000007094989,0.000003526063,0.0003122675,0.00001540202,0.9925615,0.000008829638,0.00001716097,0.004945212],"study_design_scores_gemma":[0.001283536,0.0001059594,0.01112016,0.00002935755,0.00009979954,0.00005561371,0.00002396499,0.006206008,0.9807946,0.00004587653,0.00006994632,0.0001651947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964508,0.0002105359,0.0001138356,0.0007139788,0.0007381675,0.001623124,0.0001110358,0.0000248401,0.00001372699],"genre_scores_gemma":[0.9984804,0.0006112815,0.000007756063,0.0005447495,0.0001826569,0.000125208,0.000006561025,0.00003038837,0.00001100544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01176695,"threshold_uncertainty_score":0.6763314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299426094232143,"score_gpt":0.3179845904632411,"score_spread":0.2880419810400268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}