{"id":"W2033759470","doi":"10.1002/syn.21541","title":"Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2‐(4,5‐Dihydro‐1<i>H</i>‐imidazol‐2‐yl)‐1‐ methyl‐1<i>H</i>‐indole), for the imidazoline<sub>2</sub> binding site","year":2012,"lang":"en","type":"article","venue":"Synapse","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Radioligand; Positron emission tomography; In vivo; Ex vivo; Ligand (biochemistry); Human brain; Chemistry; Radiosynthesis; In vitro; Imidazoline receptor; Binding potential; Neuroscience; Pharmacology; Biophysics; Receptor; Biochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003033945,0.000468517,0.0002545221,0.0001185725,0.00011119,0.0001855041,0.0003465636,0.0003049556,0.001103711],"category_scores_gemma":[0.0002555804,0.0001174239,0.0001360908,0.0001403173,0.0001902108,0.0002042507,0.000107189,0.0003619677,0.0004721092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002282489,"about_ca_system_score_gemma":0.0002490254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009057567,"about_ca_topic_score_gemma":0.001577108,"domain_scores_codex":[0.9999135,0.00003361167,0.000004821608,0.00001022056,0.00001474283,0.00002313739],"domain_scores_gemma":[0.9998977,0.00003122809,0.00002097095,0.000009118085,0.0000254662,0.00001546991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002270559,0.00009262253,0.00009417126,0.00004281742,0.000004589214,0.0000432292,0.00001999572,0.0002576671,0.9964033,0.00007338067,0.00006072585,0.002680374],"study_design_scores_gemma":[0.00002874456,0.002958368,0.0007281955,0.000004374243,0.00002779607,0.0002487116,0.00002043347,0.0006532715,0.9930376,0.00001996895,0.002267176,0.000005271434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703403,0.004494094,0.02002597,0.0001234311,0.0000315375,0.0002687258,0.0007216283,0.0001038621,0.003890499],"genre_scores_gemma":[0.9657188,0.004457628,0.02214286,0.0000852821,0.00002606469,0.0001841099,0.001855167,0.00003557671,0.005494531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103711,"threshold_uncertainty_score":0.003692269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299426094232143,"score_gpt":0.3179845904632411,"score_spread":0.2880419810400268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}