{"id":"W2033773507","doi":"10.1182/blood-2010-07-290551","title":"Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Factor XII; Coagulation; Fibrinogen; Chemistry; Glycoprotein; Partial thromboplastin time; Thromboplastin; Biophysics; Internal medicine; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001128322,0.0002061678,0.0002018007,0.0000976272,0.00008355307,0.0001694932,0.0001119728,0.0001800816,0.001089805],"category_scores_gemma":[0.0001471802,0.00007280433,0.0001393815,0.00007450527,0.0001781777,0.0001040265,0.0001629232,0.0002693394,0.000273586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001373185,"about_ca_system_score_gemma":0.00008161196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003199622,"about_ca_topic_score_gemma":0.0004042159,"domain_scores_codex":[0.9998581,0.00004398437,0.00000617523,0.00001666779,0.00003539465,0.000039604],"domain_scores_gemma":[0.9999352,0.00001803862,0.00001460014,0.000007559665,0.000004469041,0.00002029303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008322756,0.00002454018,0.0002712903,0.000024806,0.000007126612,0.00004834611,0.000006586276,0.00001746557,0.9980245,0.00004958099,0.00005075067,0.001391824],"study_design_scores_gemma":[0.00003888495,0.0008579148,0.02550204,0.000005140208,0.00001429017,0.00070202,0.0000161288,0.000525011,0.9692724,0.00005622427,0.003006195,0.00000363738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953313,0.002125617,0.001147979,0.0000524922,0.000009991766,0.00001481967,0.00004838668,0.00002493623,0.001244425],"genre_scores_gemma":[0.9974334,0.0004576326,0.0008425869,0.00003521929,0.000009443871,0.000008299772,0.0001249484,0.000006256745,0.001082433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001089805,"threshold_uncertainty_score":0.003645778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04204314758377809,"score_gpt":0.2336331342948555,"score_spread":0.1915899867110774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}