{"id":"W2033782813","doi":"10.1016/j.sbi.2007.01.009","title":"Atomic-level characterization of disordered protein ensembles","year":2007,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":440,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation","funders":"","keywords":"Conformational isomerism; Intrinsically disordered proteins; Folding (DSP implementation); Conformational ensembles; Protein folding; Molecular dynamics; Characterization (materials science); Chemistry; Chemical physics; Statistical physics; Physics; Computational chemistry; Nanotechnology; Materials science; Molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001596927,0.0004915633,0.001077841,0.0002482108,0.00004119998,0.00001042741,0.0004272369,0.000824306,0.00001618122],"category_scores_gemma":[0.00008057629,0.0003922181,0.0003042386,0.0002565507,0.0001874477,0.000005262235,0.0002411684,0.0003416262,0.000003547844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004081437,"about_ca_system_score_gemma":0.0002051622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009507922,"about_ca_topic_score_gemma":0.0000066456,"domain_scores_codex":[0.9977175,0.0002108925,0.0009507299,0.0006355134,0.00009724375,0.0003881439],"domain_scores_gemma":[0.9986908,0.00002019034,0.000686446,0.0004522827,0.00008604045,0.00006421268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004331774,0.00001425673,0.0001359795,0.005873915,0.0000499488,1.729785e-7,0.00001274661,1.982457e-7,0.00976298,0.001541647,0.00001201112,0.9825528],"study_design_scores_gemma":[0.0004245109,0.0001576554,0.0003505574,0.002784009,0.00003442947,0.00002533259,0.000003757415,0.0000085294,0.0007008991,0.0007185259,0.9942397,0.0005520199],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01286205,0.9811077,0.001054324,0.000005203957,0.00282509,0.001236915,0.0008729889,0.00001273205,0.00002304327],"genre_scores_gemma":[0.002821153,0.9821434,0.0002978148,0.000004006965,0.0006675931,0.00009327372,0.01390634,0.00004209936,0.00002432073],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9942278,"threshold_uncertainty_score":0.999853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07078399459000505,"score_gpt":0.3826314836482477,"score_spread":0.3118474890582427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}