{"id":"W2033796514","doi":"10.1126/science.1070925","title":"Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease","year":2002,"lang":"en","type":"article","venue":"Science","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":529,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Proteolysis; Signal peptide; Signal peptidase; Biochemistry; Proteases; Biology; Protease; Aspartic acid; Peptide sequence; Presenilin; Epitope; Enzyme; Amino acid; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004597618,0.00007369665,0.0001386501,0.000230488,0.0001141018,0.00003018123,0.0001373315,0.0000248036,0.001263746],"category_scores_gemma":[0.0004502161,0.00006259072,0.00006901554,0.00135241,0.0005240888,0.0002255355,0.00003261294,0.00008490595,0.0003528465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003762365,"about_ca_system_score_gemma":0.00009594629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007800104,"about_ca_topic_score_gemma":0.000001981775,"domain_scores_codex":[0.9985934,0.00002372882,0.0002974506,0.0002738084,0.0006036105,0.0002080012],"domain_scores_gemma":[0.9989914,0.00002025232,0.0001220193,0.0003262764,0.0003549156,0.0001851063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001629611,0.0002132784,0.002734241,0.00004003047,0.000006367846,0.00001103165,0.000210387,0.00003617012,0.9945986,0.0001118945,0.0008161003,0.001205621],"study_design_scores_gemma":[0.0006251312,0.0002385353,0.0240799,0.0002512,0.00006907197,0.00004026217,0.0001938868,0.06826568,0.905237,0.0002385117,0.0006093867,0.0001514399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951943,0.00005688988,0.0004235372,0.0007809807,0.00001998155,0.0002440658,0.00000422458,0.00004083468,0.003235196],"genre_scores_gemma":[0.9928604,0.000004991656,0.0002912794,0.0001355991,0.00004389916,0.00001034762,0.000002535693,0.00000477997,0.006646187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08936158,"threshold_uncertainty_score":0.9996492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105292282147307,"score_gpt":0.2935950151121957,"score_spread":0.2625420922907226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}