{"id":"W2033796514","doi":"10.1126/science.1070925","title":"Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease","year":2002,"lang":"en","type":"article","venue":"Science","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":529,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Proteolysis; Signal peptide; Signal peptidase; Biochemistry; Proteases; Biology; Protease; Aspartic acid; Peptide sequence; Presenilin; Epitope; Enzyme; Amino acid; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673783,0.0002399695,0.0001684864,0.0004042103,0.0001142723,0.0002776373,0.0001067085,0.0003141542,0.0004714707],"category_scores_gemma":[0.0002055371,0.00009145239,0.0001302619,0.0001379476,0.0002022148,0.0001501133,0.0001446989,0.0002842259,0.0002356795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002234952,"about_ca_system_score_gemma":0.0002486143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003165799,"about_ca_topic_score_gemma":0.0004202912,"domain_scores_codex":[0.9999428,0.000006852063,0.000006383305,0.00001248228,0.00002032053,0.00001113256],"domain_scores_gemma":[0.9999074,0.0000120046,0.00001563392,0.00000502396,0.00001956401,0.00004044281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003118911,0.00004133114,0.002439569,0.0001057448,0.00001280761,0.001220456,0.0000338537,0.00007100836,0.9782283,0.0003523535,0.0003159521,0.01686662],"study_design_scores_gemma":[0.00007501749,0.001258051,0.03970913,0.0000294241,0.00009506489,0.01020387,0.00008130285,0.001489157,0.9175836,0.0004398272,0.02902273,0.00001282737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789897,0.01145942,0.005818598,0.0004536536,0.00006668162,0.00007556103,0.0004040078,0.0000417228,0.002690754],"genre_scores_gemma":[0.9752591,0.007498736,0.01124395,0.0001967831,0.00004728708,0.0000213142,0.001896208,0.000008098727,0.003828599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004714707,"threshold_uncertainty_score":0.001621604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105292282147307,"score_gpt":0.2935950151121957,"score_spread":0.2625420922907226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}