{"id":"W2033806536","doi":"10.3109/10408363.2014.950407","title":"Is personalized medicine a dream or a reality?","year":2014,"lang":"en","type":"review","venue":"Critical Reviews in Clinical Laboratory Sciences","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"U.S. Public Health Service","keywords":"Pharmacogenomics; VKORC1; Personalized medicine; Medicine; Warfarin; Precision medicine; Pharmacogenetics; Drug; CYP2C9; Intensive care medicine; Bioinformatics; Pharmacology; Internal medicine; Biology; Genetics; Gene; Cytochrome P450; Atrial fibrillation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch","research_integrity","insufficient_payload"],"category_scores_codex":[0.03919384,0.0009634547,0.006877943,0.0003822505,0.0004218278,0.00007418439,0.002155039,0.00155141,0.008457319],"category_scores_gemma":[0.03909889,0.0005727918,0.001079499,0.00266262,0.008651409,0.0001703895,0.0003689751,0.003587368,0.001378027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008695832,"about_ca_system_score_gemma":0.001818254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009065593,"about_ca_topic_score_gemma":0.00001395299,"domain_scores_codex":[0.9772887,0.01363907,0.005274231,0.001849849,0.0007243386,0.001223858],"domain_scores_gemma":[0.9756568,0.02092972,0.0009670392,0.0008100577,0.000317292,0.001319054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004216371,0.0003937581,0.00006155763,0.01115947,0.00006961334,0.0000773694,0.00009168527,1.448773e-7,9.884047e-7,0.01142136,0.04991436,0.9267675],"study_design_scores_gemma":[0.0008240929,0.0003182551,0.000005944865,0.009979858,0.001602582,0.0000184618,0.00002168231,0.00007861656,0.000001120464,0.001371094,0.9850902,0.0006880824],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000008538277,0.9840928,0.00003875653,0.002955466,0.005105949,0.00151712,0.0003159906,0.00006233391,0.005903001],"genre_scores_gemma":[0.00001396298,0.9731904,0.0005294682,0.02263822,0.002530471,0.0003730922,0.00002115919,0.00005267361,0.0006505802],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9351758,"threshold_uncertainty_score":0.9997448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7021953646493445,"score_gpt":0.6928524729234234,"score_spread":0.009342891725921065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}