{"id":"W2033846692","doi":"10.1210/en.2013-1735","title":"IGF-I Stimulates CCN5/WISP2 Gene Expression in Pancreatic β-Cells, Which Promotes Cell Proliferation and Survival Against Streptozotocin","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; McGill University","keywords":"Biology; Islet; Streptozotocin; Cell biology; Protein kinase B; Cell growth; Insulinoma; Internal medicine; Endocrinology; Kinase; Molecular biology; Signal transduction; Insulin; Biochemistry; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002069931,0.0002080103,0.0002483998,0.0001205598,0.00007626926,0.00002905702,0.0001713482,0.0001527252,0.00003020225],"category_scores_gemma":[0.0003609834,0.0001978951,0.00003099285,0.0001127876,0.00008135512,0.000008430484,0.0002424152,0.0002038393,0.00001767671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002821366,"about_ca_system_score_gemma":0.00006703669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007054648,"about_ca_topic_score_gemma":0.0003339427,"domain_scores_codex":[0.998131,0.0003937747,0.0002389929,0.0005860527,0.0001369143,0.0005132992],"domain_scores_gemma":[0.9992743,0.0001001974,0.00006904392,0.0003545268,0.0001101329,0.00009186965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008626794,0.00009346625,0.09773378,0.00004286218,0.00001223631,0.000007674003,0.00008389947,0.00006819336,0.8998362,0.00002764314,0.00006492576,0.00194289],"study_design_scores_gemma":[0.001386633,0.0004683108,0.02430137,0.00001446447,0.000006614006,0.000008741659,0.00005018929,0.0007522154,0.9714716,0.0001079701,0.001224457,0.0002074461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973369,0.0004768523,0.0006706496,0.0001658427,0.0000923983,0.0005954966,0.000009895524,0.00002331049,0.0006286638],"genre_scores_gemma":[0.9985217,0.0001543822,0.0005592927,0.00003418432,0.0001597379,0.0001072638,0.0001053189,0.00002986592,0.0003282239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07343242,"threshold_uncertainty_score":0.8069928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264899432347495,"score_gpt":0.2641621253863608,"score_spread":0.2515131310628859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}