{"id":"W2033846692","doi":"10.1210/en.2013-1735","title":"IGF-I Stimulates CCN5/WISP2 Gene Expression in Pancreatic β-Cells, Which Promotes Cell Proliferation and Survival Against Streptozotocin","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China; McGill University","keywords":"Biology; Islet; Streptozotocin; Cell biology; Protein kinase B; Cell growth; Insulinoma; Internal medicine; Endocrinology; Kinase; Molecular biology; Signal transduction; Insulin; Biochemistry; Medicine; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007151374,0.0003433519,0.0001641739,0.0001831775,0.00009294701,0.0001556969,0.00009568735,0.0001145384,0.0008173579],"category_scores_gemma":[0.0000592064,0.000104379,0.0002199764,0.0001568677,0.0001380229,0.0001118121,0.000150598,0.0003543291,0.0001681078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003555825,"about_ca_system_score_gemma":0.0001632943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067222,"about_ca_topic_score_gemma":0.001562852,"domain_scores_codex":[0.9999177,0.000009823777,0.0000077,0.0000207707,0.00002654389,0.00001731543],"domain_scores_gemma":[0.9999517,0.000006801699,0.00001303426,0.000005314363,0.000005315098,0.00001780386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003888636,0.000005542054,0.0001328623,0.0000141695,0.00000172855,0.0000173801,0.000004104863,0.00001827336,0.9995044,0.00001571521,0.000009685823,0.000237183],"study_design_scores_gemma":[0.000007923662,0.0001190399,0.0127453,0.000005442945,0.000008818215,0.0001046148,0.00002180083,0.0008791303,0.9848137,0.00001604467,0.00127513,0.000003145515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957373,0.001037998,0.001435315,0.00005465652,0.00002243007,0.00001782376,0.0006572451,0.0000412904,0.0009958445],"genre_scores_gemma":[0.9917745,0.0008564559,0.002895707,0.00008145953,0.00001020831,0.00005662709,0.001879491,0.00001825261,0.002427487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001067222,"threshold_uncertainty_score":0.002734363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01264899432347495,"score_gpt":0.2641621253863608,"score_spread":0.2515131310628859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}