{"id":"W2033847468","doi":"10.1152/ajplung.00409.2005","title":"Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation","year":2006,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"Chemistry; Wortmannin; Mecamylamine; Thapsigargin; Cell biology; Phosphatidylinositol; Agonist; Calcium in biology; Pharmacology; Nicotinic agonist; Endocrinology; Endoplasmic reticulum; Receptor; Signal transduction; Internal medicine; Biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048362,0.0002242021,0.0002303696,0.0001513445,0.0001198389,0.0001485579,0.0001223782,0.0002073534,0.001037278],"category_scores_gemma":[0.00007696263,0.0001081342,0.0001889756,0.0001468264,0.0001325875,0.0001418957,0.0001311009,0.0005811105,0.0002609168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343999,"about_ca_system_score_gemma":0.000247773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004879492,"about_ca_topic_score_gemma":0.001001122,"domain_scores_codex":[0.9998606,0.00002096773,0.00001723793,0.00002089013,0.00003146021,0.00004872029],"domain_scores_gemma":[0.9999563,0.000006225122,0.00001257347,0.000004736166,0.000006434292,0.00001387258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004836644,0.00006220017,0.0002876957,0.00009224142,0.00001058665,0.0000663656,0.00001441089,0.00002341962,0.9948741,0.00003866865,0.00005947976,0.003987243],"study_design_scores_gemma":[0.0001491687,0.001481695,0.01820664,0.00001612701,0.00006133642,0.0003348591,0.00005967719,0.0006577087,0.9756359,0.00007941762,0.003311751,0.000005721445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862299,0.0093274,0.0022577,0.0002721271,0.00007028853,0.00003840823,0.0003227428,0.00007537286,0.001405997],"genre_scores_gemma":[0.9897597,0.004895424,0.00250654,0.0002111724,0.0000394971,0.0001057151,0.0003799988,0.000008612824,0.002093299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037278,"threshold_uncertainty_score":0.003470004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003253995171690969,"score_gpt":0.2303730715100839,"score_spread":0.2271190763383929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}