{"id":"W2033898397","doi":"10.1074/jbc.m806127200","title":"Genetic and Biochemical Analysis of Yeast and Human Cap Trimethylguanosine Synthase","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; Ontario Genomics; Ontario Genomics Institute; Genome Canada","keywords":"Biology; RNA splicing; Spliceosome; snRNP; Small nuclear ribonucleoprotein; Genetics; Gene; Biochemistry; Cell biology; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009814497,0.0003675668,0.0001883054,0.0002226198,0.0001042874,0.0001791798,0.0001477918,0.0001917393,0.0008276642],"category_scores_gemma":[0.0001280905,0.0001263599,0.0003071369,0.0002300202,0.0001138978,0.0000745435,0.0001693708,0.000218439,0.0005485023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002572217,"about_ca_system_score_gemma":0.0001736329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001700039,"about_ca_topic_score_gemma":0.001929447,"domain_scores_codex":[0.999929,0.000009988837,0.000008588017,0.00001930793,0.00002098977,0.00001213204],"domain_scores_gemma":[0.9999167,0.00001460087,0.00001652981,0.00001484968,0.00001396092,0.00002334339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001145028,0.00001547187,0.000407262,0.00004106637,0.000009362864,0.0001177571,0.00001244555,0.0001119513,0.9974816,0.0001384971,0.00004958773,0.001500369],"study_design_scores_gemma":[0.00001860386,0.0001898048,0.0128027,0.000008814497,0.00004311544,0.00103417,0.00005054343,0.001473093,0.9737617,0.0001313983,0.01047598,0.00001004882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853373,0.003442251,0.004768976,0.0001287549,0.00004403423,0.00004363126,0.003845447,0.000134331,0.002255262],"genre_scores_gemma":[0.9785645,0.001614148,0.005048981,0.00007248254,0.00001028025,0.00003436857,0.0108684,0.00004350577,0.003743456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700039,"threshold_uncertainty_score":0.003380299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02432177785428615,"score_gpt":0.2889092025276903,"score_spread":0.2645874246734042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}