{"id":"W2033914262","doi":"10.1021/jm800621x","title":"Chlorogenic Acid Derivatives with Alkyl Chains of Different Lengths and Orientations: Potent α-Glucosidase Inhibitors","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Natural Antidiabetic Agents Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Chemistry; Chlorogenic acid; Stereochemistry; Potency; Glucosidases; Alkyl; Inhibitory postsynaptic potential; Structure–activity relationship; Biochemistry; Enzyme; In vitro; Organic chemistry; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009825538,0.0003281863,0.0001836444,0.0001748047,0.0001082234,0.0001427333,0.0001836958,0.0001535598,0.000596376],"category_scores_gemma":[0.00009764591,0.0001039386,0.0001554862,0.0002390294,0.0001634309,0.000210945,0.0001904284,0.0003509401,0.0001894649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001646655,"about_ca_system_score_gemma":0.0001953019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004929272,"about_ca_topic_score_gemma":0.001243761,"domain_scores_codex":[0.9999222,0.00001519309,0.000007857445,0.000009966113,0.0000188491,0.00002600326],"domain_scores_gemma":[0.9999142,0.000009990632,0.00002563819,0.0000093575,0.00001379366,0.00002704503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003913636,0.00006084373,0.0003435526,0.0001246874,0.00001395127,0.0001277367,0.00002921615,0.0002871678,0.9922059,0.0002205583,0.00005380112,0.006141183],"study_design_scores_gemma":[0.00004379579,0.000854851,0.002050159,0.0000105776,0.00002867081,0.0002624883,0.00002569927,0.0003051562,0.9932404,0.00003947951,0.003128375,0.0000105045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884144,0.005512301,0.002428767,0.00007019723,0.00002387878,0.00004186203,0.0002334952,0.00003365515,0.003241398],"genre_scores_gemma":[0.9921112,0.00360445,0.002779099,0.00004877186,0.00001108197,0.00002062328,0.0002470574,0.000007889807,0.001169796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000596376,"threshold_uncertainty_score":0.001995087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01132305955236691,"score_gpt":0.2373144831574665,"score_spread":0.2259914236050996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}