{"id":"W2033941177","doi":"10.3389/fgene.2012.00081","title":"The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells","year":2012,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Science Council; Scottish Rite Charitable Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Manitoba Medical Service Foundation; Manitoba Health Research Council; Health Sciences Centre Foundation","keywords":"Epigenetics; Epigenetic regulation of neurogenesis; Biology; Chromatin; Embryonic stem cell; DNA methylation; Histone; Stem cell; Epigenomics; Cellular differentiation; Cell biology; Genetics; Gene; Gene expression; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002835242,0.0001881794,0.0001899238,0.0002998876,0.0002699353,0.0006520191,0.0002392921,0.000399312,0.0008232249],"category_scores_gemma":[0.0003288767,0.0001727451,0.0002061341,0.0003122054,0.0005060621,0.0006466333,0.0004142134,0.0007509112,0.0007753659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004374777,"about_ca_system_score_gemma":0.0005946848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00066511,"about_ca_topic_score_gemma":0.0009267317,"domain_scores_codex":[0.9998811,0.00001813095,0.00001166138,0.00002163801,0.00005374369,0.00001366946],"domain_scores_gemma":[0.9999299,0.000009890585,0.00001566125,0.000008639993,0.00001970304,0.00001630119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000119187,0.00002473913,0.002198091,0.0005152998,0.00002920542,0.00110202,0.0006971275,0.0008495457,0.8300514,0.0392346,0.001444614,0.1237341],"study_design_scores_gemma":[0.00002918394,0.0004690443,0.02848227,0.0002879102,0.0000816615,0.005222215,0.0008954484,0.001569014,0.5618871,0.02631819,0.3746913,0.00006674419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5306804,0.2330863,0.1620269,0.005990994,0.001587128,0.0001996439,0.002180265,0.0006468709,0.0636015],"genre_scores_gemma":[0.7618936,0.1317441,0.07155507,0.001597978,0.000379887,0.0001343902,0.001386143,0.0001408862,0.03116802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008232249,"threshold_uncertainty_score":0.003174186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008036797028511034,"score_gpt":0.2292707486444092,"score_spread":0.2212339516158982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}