{"id":"W2033941177","doi":"10.3389/fgene.2012.00081","title":"The Genetic and Epigenetic Journey of Embryonic Stem Cells into Mature Neural Cells","year":2012,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Science Council; Scottish Rite Charitable Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Manitoba Medical Service Foundation; Manitoba Health Research Council; Health Sciences Centre Foundation","keywords":"Epigenetics; Epigenetic regulation of neurogenesis; Biology; Chromatin; Embryonic stem cell; DNA methylation; Histone; Stem cell; Epigenomics; Cellular differentiation; Cell biology; Genetics; Gene; Gene expression; Chromatin remodeling","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004072936,0.0002438293,0.0002415523,0.00008402156,0.0001331324,0.00003989925,0.0003205532,0.0002684384,0.000002574484],"category_scores_gemma":[0.00001672174,0.0002045357,0.00008836357,0.0001615987,0.0002254399,0.000005134237,0.0001815519,0.0001811733,0.000002134638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002480389,"about_ca_system_score_gemma":0.00005657036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008415692,"about_ca_topic_score_gemma":0.00002514183,"domain_scores_codex":[0.9983371,0.0001925027,0.0004323703,0.0003099679,0.0002196493,0.0005083504],"domain_scores_gemma":[0.9989769,0.00003217585,0.0002021138,0.0005324308,0.00008105938,0.0001752893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006771421,0.00007721985,0.1226269,0.00007485977,0.00006702285,0.000001477997,0.0004905523,0.002710129,0.8217623,0.00001358732,0.002228881,0.04987937],"study_design_scores_gemma":[0.0005156792,0.0002529322,0.03959015,0.00001651279,0.00005173872,0.000003727717,0.0004214369,0.001714301,0.9253344,0.0003177976,0.03145644,0.0003248836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8582906,0.1340897,0.005671879,0.00007127725,0.00150002,0.0002807771,0.000009623423,0.000004784007,0.00008129093],"genre_scores_gemma":[0.9629806,0.02327083,0.01296974,0.00004981373,0.0002738079,0.00001541445,0.000008324867,0.00004528125,0.0003862299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1108189,"threshold_uncertainty_score":0.8340724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008036797028511034,"score_gpt":0.2292707486444092,"score_spread":0.2212339516158982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}