{"id":"W2033955364","doi":"10.1371/journal.pone.0030528","title":"Biochemical Discrimination between Selenium and Sulfur 2: Mechanistic Investigation of the Selenium Specificity of Human Selenocysteine Lyase","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Selenium in Biological Systems","field":"Nursing","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Cancerfonden; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Ontario Genomics; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"Selenocysteine; Selenium; Cysteine; Chemistry; Enzyme; Substrate (aquarium); Function (biology); Biochemistry; Sulfur; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002655653,0.0002297208,0.0001929116,0.00009503925,0.0001549423,0.0002030919,0.0002503578,0.000522813,0.0006466437],"category_scores_gemma":[0.0002360712,0.0001404319,0.0001709352,0.0001053743,0.0002692077,0.0003536804,0.0001441068,0.0004028172,0.0001503327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603157,"about_ca_system_score_gemma":0.0001347135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005196354,"about_ca_topic_score_gemma":0.0004922384,"domain_scores_codex":[0.9998997,0.00001989151,0.000005591461,0.00002975325,0.00002660197,0.00001840633],"domain_scores_gemma":[0.9999228,0.00003048114,0.00001699527,0.000009558982,0.00001158762,0.000008558155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001928326,0.00002998129,0.0004598711,0.0000349561,0.00000576644,0.00009690574,0.00003963807,0.0001827212,0.9972628,0.0002443919,0.00002366205,0.001426306],"study_design_scores_gemma":[0.000009813589,0.000175603,0.00153371,0.000001696758,0.00000528582,0.0002279987,0.0000338172,0.001497472,0.995987,0.0001244197,0.0003963255,0.000006797862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963089,0.0007194654,0.002300681,0.0001088872,0.000008431866,0.00000955013,0.00005883645,0.00002186588,0.0004634295],"genre_scores_gemma":[0.9975297,0.0002930873,0.001636626,0.00002427036,0.000004337176,0.00000510447,0.00009352004,0.000003651119,0.0004098589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006466437,"threshold_uncertainty_score":0.002163291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08592680759338993,"score_gpt":0.259401522900057,"score_spread":0.1734747153066671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}