{"id":"W2033978760","doi":"10.1001/archdermatol.2009.347","title":"Extent and Clinical Consequences of Antibody Formation Against Adalimumab in Patients With Plaque Psoriasis","year":2010,"lang":"en","type":"article","venue":"Archives of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Adalimumab; Medicine; Psoriasis; Internal medicine; Titer; Psoriasis Area and Severity Index; Gastroenterology; Dermatology; Antibody; Immunology; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005941286,0.0001184739,0.000389819,0.0001635968,0.00003856278,0.000001927277,0.0001155358,0.0001482694,0.0000135691],"category_scores_gemma":[0.00004838384,0.00008951021,0.00005410241,0.00005781659,0.0008411905,0.00008055948,0.00004423064,0.0001493606,0.000004874517],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000188178,"about_ca_system_score_gemma":0.00004858745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003258171,"about_ca_topic_score_gemma":0.0001438337,"domain_scores_codex":[0.99893,0.0002293705,0.0004692832,0.0001714456,0.00002498814,0.0001748744],"domain_scores_gemma":[0.9990684,0.0004618709,0.0002526653,0.0001710413,0.00002720724,0.00001876215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009210005,0.0003649408,0.9306402,0.00004030573,0.0001570749,0.000008190019,0.0004805471,5.243938e-7,0.03985904,0.001174136,0.00001307868,0.02634095],"study_design_scores_gemma":[0.006096915,0.000320131,0.9305907,0.00005009134,0.00006882049,0.00008416714,0.0001285443,0.00000629884,0.06189111,0.0004015957,0.0002490222,0.0001125501],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985092,0.0002215685,0.00004963411,0.0001532838,0.0002308025,0.0002017306,0.00004639963,0.000009983378,0.0005773641],"genre_scores_gemma":[0.9988453,0.0002947011,0.0006334336,0.00002610172,0.000004305338,0.000007300388,0.0001755621,0.000005783787,0.00000755323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0262284,"threshold_uncertainty_score":0.365012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002022138102678,"score_gpt":0.2573756866100511,"score_spread":0.2473554652290243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}