{"id":"W2033983577","doi":"10.1016/j.molimm.2009.09.037","title":"The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production","year":2009,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"PPADS; Suramin; Receptor; Chemokine; Receptor antagonist; CXCL1; Neutrophil extracellular traps; Pharmacology; Biology; Immunology; Chemistry; Internal medicine; Antagonist; Inflammation; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002446195,0.0001429538,0.0001298039,0.00005030935,0.0001385769,0.00001630952,0.0001366152,0.0001503151,0.000002312723],"category_scores_gemma":[0.0000703929,0.0001005634,0.00005460603,0.0001541011,0.0001163259,0.000007247009,0.00004101938,0.0001456405,0.000001649978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001141849,"about_ca_system_score_gemma":0.00002764584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006465472,"about_ca_topic_score_gemma":0.00002666345,"domain_scores_codex":[0.9989696,0.0002067266,0.0002626871,0.0002707593,0.00009135428,0.0001988417],"domain_scores_gemma":[0.999441,0.00001583216,0.0001224593,0.0003257079,0.00008004178,0.00001495727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001708626,0.00007044858,0.0001767998,0.000005385428,0.00002666137,0.000005579137,0.0001085608,0.0000451315,0.9967568,0.0002825234,0.0003808287,0.001970456],"study_design_scores_gemma":[0.0004311676,0.0007353509,0.005418242,0.0000136368,0.00001665287,0.0000807687,0.0001692747,0.00002074802,0.9882226,0.0004021688,0.004373188,0.0001162164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986818,0.005537181,0.0002510894,0.006931702,0.0001179227,0.0002475332,0.000001592041,0.000008249838,0.00008676355],"genre_scores_gemma":[0.9984987,0.0007381604,0.0001031303,0.0003429829,0.0001139796,0.00002220621,0.0001142957,0.00001077251,0.00005576579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01168074,"threshold_uncertainty_score":0.4100856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004893460316743698,"score_gpt":0.2213710535737763,"score_spread":0.2164775932570326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}