{"id":"W2033989463","doi":"10.1158/1538-7445.am10-396","title":"Abstract 396: Reovirus successfully purges multiple myeloma <i>ex vivo</i> and does not affect human CD34+ cell engraftment in a murine transplantation model.","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Calgary Laboratory Services","funders":"","keywords":"Stem cell; Ex vivo; CD34; Transplantation; CD38; Multiple myeloma; Apheresis; Bone marrow; Cancer research; Biology; Immunology; Medicine; In vivo; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002197467,0.0008581729,0.000335991,0.0003512611,0.0001847976,0.0003852065,0.0004763669,0.0007133356,0.003420884],"category_scores_gemma":[0.0001304251,0.0001744921,0.0004314579,0.0001866398,0.00025863,0.0003504773,0.000187118,0.001023267,0.001145419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003145408,"about_ca_system_score_gemma":0.0002074008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008300004,"about_ca_topic_score_gemma":0.0006374679,"domain_scores_codex":[0.9997918,0.00002835581,0.00002028937,0.00004835949,0.00005745505,0.00005376247],"domain_scores_gemma":[0.9997926,0.00004360869,0.0000699683,0.00003760982,0.00001496989,0.00004121698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002403962,0.0001388207,0.0000762799,0.00004932145,0.000006607828,0.00006169981,0.0000123389,0.00007187537,0.9977177,0.00009517128,0.0001945913,0.001335123],"study_design_scores_gemma":[0.00003092447,0.0008092421,0.0007501527,0.00001016949,0.00001435997,0.0002343446,0.000004297171,0.000261543,0.995693,0.00002410174,0.002164736,0.0000030505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735616,0.003159121,0.01115804,0.0003008689,0.0002116249,0.0002278821,0.003263953,0.0007943564,0.007322565],"genre_scores_gemma":[0.9714399,0.001724315,0.008302808,0.0001496187,0.00004806981,0.0001740371,0.005598222,0.0002221568,0.01234088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003420884,"threshold_uncertainty_score":0.01144403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03050984168479046,"score_gpt":0.3661154306735083,"score_spread":0.3356055889887178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}