{"id":"W2033995262","doi":"10.1016/j.str.2010.01.020","title":"Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase","year":2010,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Canada Research Chairs; University of Toronto; Hospital for Sick Children","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust; U.S. Department of Energy","keywords":"Ubiquitin ligase; Intrinsically disordered proteins; Protein subunit; Cell division control protein 4; Ubiquitin; Function (biology); Ubiquitin-Protein Ligases; Biology; Cell biology; Chemistry; Biophysics; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002431923,0.000520888,0.0004354597,0.000389197,0.001031065,0.001063412,0.000689222,0.0007160239,0.001206343],"category_scores_gemma":[0.0004011209,0.0003586091,0.0002805927,0.0003160986,0.0007713028,0.0006560877,0.0003990809,0.0006414228,0.0003036938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001289621,"about_ca_system_score_gemma":0.0004813778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00165581,"about_ca_topic_score_gemma":0.001242623,"domain_scores_codex":[0.9998741,0.0000165734,0.0000119,0.00003146303,0.00003959406,0.00002633899],"domain_scores_gemma":[0.9997259,0.00003065876,0.00007688737,0.00002199392,0.0000316273,0.0001130101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001007434,0.0001657949,0.004325599,0.0001157772,0.00007253271,0.003311197,0.0001915157,0.007048544,0.9738236,0.005380868,0.0004780517,0.004079028],"study_design_scores_gemma":[0.0002767945,0.0005216887,0.02719698,0.00003176536,0.0001961403,0.006552544,0.0005365176,0.1140783,0.8372046,0.006139698,0.007147794,0.0001173389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965259,0.0005223217,0.001804254,0.0002541584,0.0000256651,0.000006501014,0.00005598176,0.00007949293,0.000725679],"genre_scores_gemma":[0.9989588,0.00006325585,0.0005792164,0.00003897522,0.000004688296,0.000001896943,0.00007338171,0.000007959415,0.0002718436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00165581,"threshold_uncertainty_score":0.009356916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004916969622908354,"score_gpt":0.22665955654145,"score_spread":0.2217425869185417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}