{"id":"W2033995262","doi":"10.1016/j.str.2010.01.020","title":"Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase","year":2010,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":277,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Canada Research Chairs; University of Toronto; Hospital for Sick Children","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust; U.S. Department of Energy","keywords":"Ubiquitin ligase; Intrinsically disordered proteins; Protein subunit; Cell division control protein 4; Ubiquitin; Function (biology); Ubiquitin-Protein Ligases; Biology; Cell biology; Chemistry; Biophysics; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007549571,0.0001431057,0.0001408402,0.00003180955,0.0001000222,0.00001326675,0.0003893031,0.0001560876,0.00006657391],"category_scores_gemma":[0.00004744464,0.00007997295,0.00005221101,0.0001663557,0.0003008657,0.000005229674,0.00009734144,0.0002990402,1.983836e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005370798,"about_ca_system_score_gemma":0.0001042225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006411145,"about_ca_topic_score_gemma":0.008244249,"domain_scores_codex":[0.9992189,0.00008414419,0.0001893098,0.0002273408,0.0001194106,0.0001608946],"domain_scores_gemma":[0.998978,0.00001593729,0.000171307,0.0006723059,0.0001223601,0.00004013084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001211703,0.00002449171,0.002293841,0.00002041757,0.00002000946,1.795515e-7,0.0001456973,0.00007382579,0.9912021,0.002683964,0.00002153582,0.003392838],"study_design_scores_gemma":[0.0006936704,0.0003442837,0.2888347,0.00001256679,0.00003204084,0.000034334,0.0001885563,0.000129504,0.7025393,0.005498568,0.00153394,0.0001585549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981556,0.00002792915,0.000120353,0.0006291319,0.0000692658,0.0004028905,0.000389542,0.000006235812,0.0001990632],"genre_scores_gemma":[0.9989443,0.000002882001,0.0005528161,0.0001615047,0.00006918743,0.0000129825,0.0002134792,0.00001753464,0.00002524565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2886628,"threshold_uncertainty_score":0.4600484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004916969622908354,"score_gpt":0.22665955654145,"score_spread":0.2217425869185417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}