{"id":"W2034004457","doi":"10.1038/sj.onc.1206587","title":"Signal transduction by several KIT juxtamembrane domain mutations","year":2003,"lang":"en","type":"article","venue":"Oncogene","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Proto-Oncogene Proteins c-kit; Signal transduction; Tyrosine kinase; Mutation; Receptor tyrosine kinase; Systemic mastocytosis; Cancer research; Mutant; Cell biology; Protein kinase domain; Molecular biology; Genetics; Mast cell; Stem cell factor; Immunology; Gene; Stem cell; Progenitor cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001822029,0.0003744228,0.0001448716,0.0002393265,0.0002060214,0.0002151719,0.0002432412,0.0003162363,0.001193806],"category_scores_gemma":[0.000224275,0.0001293507,0.0002318407,0.0001331193,0.0002874147,0.0002032052,0.0002561715,0.0004135473,0.0001586388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002998212,"about_ca_system_score_gemma":0.0001425458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006324412,"about_ca_topic_score_gemma":0.0006707982,"domain_scores_codex":[0.999863,0.0000346316,0.00001769949,0.00001419246,0.00002669454,0.00004373663],"domain_scores_gemma":[0.9998989,0.00004076304,0.00002081861,0.00001260896,0.000006792175,0.00001999443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003250725,0.00003890324,0.0002580342,0.0000157348,0.000006584622,0.0003251233,0.00002267588,0.0001313252,0.9977208,0.0004355561,0.00003648109,0.0006837714],"study_design_scores_gemma":[0.00007526502,0.0004350488,0.003057438,0.0000038231,0.00002834974,0.001313796,0.00003519452,0.00118097,0.9926537,0.0001573568,0.001052614,0.000006345023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985769,0.0001707711,0.0005998015,0.0000359501,0.000009109063,0.00001079008,0.00006489341,0.00001327003,0.0005184039],"genre_scores_gemma":[0.9989919,0.000128766,0.0003541161,0.00001419623,0.000004367896,0.00001412309,0.000104221,0.000006477143,0.0003817616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001193806,"threshold_uncertainty_score":0.00399363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00677830566850542,"score_gpt":0.2074969315264497,"score_spread":0.2007186258579443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}