{"id":"W2034004457","doi":"10.1038/sj.onc.1206587","title":"Signal transduction by several KIT juxtamembrane domain mutations","year":2003,"lang":"en","type":"article","venue":"Oncogene","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":68,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Proto-Oncogene Proteins c-kit; Signal transduction; Tyrosine kinase; Mutation; Receptor tyrosine kinase; Systemic mastocytosis; Cancer research; Mutant; Cell biology; Protein kinase domain; Molecular biology; Genetics; Mast cell; Stem cell factor; Immunology; Gene; Stem cell; Progenitor cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001225239,0.0001183546,0.0001516878,0.00004612261,0.0001836649,0.000008893169,0.00006793161,0.00014071,0.01515433],"category_scores_gemma":[0.00000618999,0.0001147869,0.0000680202,0.0001027591,0.0001078344,0.00004844196,0.000004873622,0.0001326588,0.000702634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003186776,"about_ca_system_score_gemma":0.00004301149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000456066,"about_ca_topic_score_gemma":0.00002917202,"domain_scores_codex":[0.9992356,0.0001190202,0.0001771919,0.0002054927,0.00002776985,0.0002349315],"domain_scores_gemma":[0.9997469,0.00002670446,0.00004591897,0.0001256196,0.00002981765,0.00002510189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003319027,0.0001333333,0.00002941569,0.000007719356,0.00005231115,0.000003811041,0.000266188,0.0000243172,0.9848489,0.001430344,0.01093728,0.002233251],"study_design_scores_gemma":[0.001031754,0.00008999133,0.00003144341,0.000003415152,0.00002580261,0.00009141115,0.0001103004,0.000001448596,0.3321078,0.0002711839,0.6661101,0.0001253255],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9267836,0.004762465,0.01070018,0.000623054,0.00118069,0.0002895043,0.0001968797,0.0001168696,0.0553468],"genre_scores_gemma":[0.9599212,0.00005474216,0.0006519262,0.0001572284,0.00003397071,0.00001733771,0.0003602324,0.0000162161,0.03878719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6551728,"threshold_uncertainty_score":0.985746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00677830566850542,"score_gpt":0.2074969315264497,"score_spread":0.2007186258579443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}