{"id":"W2034029432","doi":"10.1016/j.taap.2012.09.012","title":"Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage","year":2012,"lang":"en","type":"article","venue":"Toxicology and Applied Pharmacology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; University of British Columbia","keywords":"Oxidative stress; Reactive oxygen species; Pancreatic islets; Apoptosis; Viability assay; Arsenic toxicity; Chemistry; Cytotoxicity; Gene knockdown; Antioxidant; Transcription factor; Cell damage; Endocrinology; Cell biology; Internal medicine; Biology; Biochemistry; Islet; Medicine; Diabetes mellitus; Toxicity; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003266451,0.0002757393,0.0003071018,0.00007824604,0.0001971487,0.00001541161,0.0003635606,0.0003718971,0.0003621741],"category_scores_gemma":[0.00002287799,0.0002319048,0.00005792286,0.0001397903,0.0001786046,0.000007817493,0.0001802595,0.0004545168,0.00008571646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002870876,"about_ca_system_score_gemma":0.00004330631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008143883,"about_ca_topic_score_gemma":0.0000123554,"domain_scores_codex":[0.9981127,0.0003243704,0.0003068011,0.0004706996,0.00008034131,0.0007050702],"domain_scores_gemma":[0.9992865,0.000136465,0.0001108425,0.0002598364,0.00002057387,0.000185785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001620543,0.0003524504,0.0005725287,0.00002025222,0.00003584765,0.000002620693,0.001482981,0.00003312565,0.9941499,0.0001851936,0.00260339,0.0003996642],"study_design_scores_gemma":[0.001588356,0.0002817236,0.005678216,0.000002088265,0.00005315094,0.00001036143,0.0008571306,0.00001856291,0.9820551,0.00006911394,0.009056842,0.0003293549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924328,0.0002926753,0.0000370219,0.0003644975,0.0003852252,0.0006428553,0.00003772885,0.00001723582,0.005789903],"genre_scores_gemma":[0.9960037,0.0001021594,0.0001896637,0.003142491,0.0001998543,0.00009094183,0.00003138731,0.00002958275,0.000210207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01209479,"threshold_uncertainty_score":0.9456805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01714953196011501,"score_gpt":0.268572306104476,"score_spread":0.251422774144361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}