{"id":"W2034043843","doi":"10.1006/biol.2002.0322","title":"Thermal Stability: A Means to Assure Tertiary Structure in Therapeutic Proteins","year":2002,"lang":"en","type":"article","venue":"Biologicals","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"","keywords":"Protein tertiary structure; Protein secondary structure; Denaturation (fissile materials); Chemistry; Protein structure; Protein folding; Chemical structure; Amino acid; Protein primary structure; Biochemistry; Crystallography; Biophysics; Peptide sequence; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001923194,0.0005664793,0.0004851681,0.0005600757,0.000697758,0.001258542,0.0005790477,0.0007807684,0.001709102],"category_scores_gemma":[0.00247683,0.0003733985,0.0003909963,0.0002666578,0.0009570773,0.001489599,0.0005745271,0.001451494,0.0008072678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004998592,"about_ca_system_score_gemma":0.0003859953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001470204,"about_ca_topic_score_gemma":0.0001760909,"domain_scores_codex":[0.9993631,0.0001960318,0.00005337576,0.00009890953,0.0002206405,0.00006799372],"domain_scores_gemma":[0.9987483,0.000303728,0.0003314645,0.0002256247,0.0002816273,0.0001092369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003005651,0.00004656226,0.0005321504,0.0001204456,0.00001675636,0.00006278168,0.0001189397,0.001320468,0.9694957,0.006381677,0.0005461251,0.02105784],"study_design_scores_gemma":[0.00001646134,0.0003470259,0.0007560697,0.00001621533,0.00002873053,0.0004302683,0.00002627902,0.003805826,0.9866583,0.002524136,0.005368507,0.00002220843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.627938,0.01255627,0.343061,0.002175552,0.0004665114,0.0001811707,0.0003139037,0.001705231,0.01160244],"genre_scores_gemma":[0.9460846,0.00199411,0.04640452,0.0004842426,0.0001906874,0.0001163176,0.0002222982,0.0003234811,0.004179688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001923194,"threshold_uncertainty_score":0.01017094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03560368562267057,"score_gpt":0.2410658868471672,"score_spread":0.2054622012244966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}