{"id":"W2034060255","doi":"10.1074/jbc.m110.192344","title":"The Proprotein Convertase PC7","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Proprotein convertase; Chemistry; PCSK9; Biochemistry; Cholesterol; Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007002953,0.0003304232,0.0001567052,0.000164491,0.0001432884,0.0004857891,0.0001725689,0.0003098891,0.0007559958],"category_scores_gemma":[0.0001447514,0.00008931134,0.0002153406,0.0001710338,0.000132695,0.0002312142,0.0001615715,0.000509884,0.0007848944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003679486,"about_ca_system_score_gemma":0.0002820341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001255242,"about_ca_topic_score_gemma":0.0006057873,"domain_scores_codex":[0.9998988,0.00001100091,0.000007100462,0.00002284223,0.00003932728,0.00002088232],"domain_scores_gemma":[0.9999355,0.00000709083,0.000008995985,0.000006340232,0.00002723167,0.00001497388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005957984,0.000007991903,0.0004266774,0.00005669257,0.000005953017,0.0003388529,0.0000168187,0.00008106598,0.9944442,0.0003760614,0.0001434599,0.004042637],"study_design_scores_gemma":[0.00001306317,0.0001129041,0.007128037,0.0000154143,0.000026866,0.002380236,0.00008393059,0.002310481,0.9682969,0.0003236061,0.01929688,0.00001169613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760057,0.007722153,0.009928259,0.0002734598,0.0001396443,0.00006837597,0.001278018,0.0001221852,0.004462194],"genre_scores_gemma":[0.9702645,0.005504075,0.009394802,0.0002001808,0.00004320531,0.00004392032,0.004533583,0.00003983939,0.009975829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001255242,"threshold_uncertainty_score":0.002669692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009295888764422876,"score_gpt":0.219614346695865,"score_spread":0.2103184579314421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}