{"id":"W2034074403","doi":"10.1126/science.1069525","title":"Induction of Cachexia in Mice by Systemically Administered Myostatin","year":2002,"lang":"en","type":"article","venue":"Science","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":899,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute","keywords":"Myostatin; Cachexia; Endocrinology; Skeletal muscle; Internal medicine; Medicine; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002773059,0.0006706317,0.0004401476,0.0005689321,0.0002563975,0.0003964756,0.000312626,0.0005680567,0.002320359],"category_scores_gemma":[0.0001622818,0.0003566055,0.0002950541,0.0002810599,0.000740319,0.0003649234,0.0002855718,0.001398644,0.0006455046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003902051,"about_ca_system_score_gemma":0.0003478916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003997024,"about_ca_topic_score_gemma":0.001296123,"domain_scores_codex":[0.9997644,0.0000377767,0.00002773318,0.00006002416,0.00005216805,0.00005788791],"domain_scores_gemma":[0.9996309,0.00004784987,0.0001343813,0.00003693942,0.0000180072,0.0001318802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002868336,0.00006138004,0.0001581768,0.00003627188,0.000008928542,0.00007485922,0.00002605929,0.00005019143,0.99778,0.0002289489,0.00005699781,0.001231413],"study_design_scores_gemma":[0.0001611787,0.001596116,0.003558296,0.00002476884,0.00004283616,0.000620773,0.00005477793,0.001127958,0.9887328,0.0001908968,0.003878872,0.00001077874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851613,0.002459983,0.007452719,0.0004330075,0.0001066762,0.0001068445,0.001381375,0.0006697702,0.00222835],"genre_scores_gemma":[0.97451,0.002657614,0.009334983,0.0002462012,0.00004566495,0.0002809374,0.001749848,0.0001924,0.01098233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002320359,"threshold_uncertainty_score":0.007762313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01243290104560558,"score_gpt":0.2468654279503784,"score_spread":0.2344325269047728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}