{"id":"W2034092309","doi":"10.1074/jbc.m806272200","title":"The Crystal Structure of Aquifex aeolicus Prephenate Dehydrogenase Reveals the Mode of Tyrosine Inhibition","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Concordia University; University of Toronto","funders":"Argonne National Laboratory; Natural Sciences and Engineering Research Council of Canada","keywords":"Aquifex aeolicus; Tyrosine; Chemistry; Crystal structure; Stereochemistry; Biochemistry; Crystallography; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002748128,0.0001089534,0.0002342485,0.000009925794,0.00009187926,0.000018065,0.0002399775,0.0001437236,0.000126879],"category_scores_gemma":[0.0002654019,0.00004526203,0.0001328892,0.00009796755,0.000227379,0.00006251074,0.00003408982,0.000207007,4.128356e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002249288,"about_ca_system_score_gemma":0.00003344879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002245934,"about_ca_topic_score_gemma":6.883002e-7,"domain_scores_codex":[0.9988922,0.00006382914,0.0005546608,0.000105305,0.0002340518,0.0001499938],"domain_scores_gemma":[0.9987113,0.0001106825,0.0007496196,0.0001834309,0.000193142,0.00005180146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002276305,0.00002366306,0.0001045922,0.00001513857,0.000008705765,0.000003157754,0.00004844721,0.0001862106,0.9987445,0.00008299464,0.0003775294,0.0001774336],"study_design_scores_gemma":[0.0002362796,0.0002056783,0.0009767158,0.00003703345,0.00001938274,0.0001642413,0.00005850399,0.00001706812,0.9875554,0.01051012,0.0001650755,0.00005449031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986078,0.000535365,0.00007353197,0.0003224511,0.00009282649,0.00005356942,0.00003878351,0.000006091068,0.0002696407],"genre_scores_gemma":[0.9992755,0.00008394002,0.0002188017,0.00008862388,0.0003000719,3.563076e-7,0.000003907389,0.000002863191,0.0000259197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01118909,"threshold_uncertainty_score":0.1845732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103278660935917,"score_gpt":0.2404587724243065,"score_spread":0.2301309063307148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}