{"id":"W2034096429","doi":"10.1213/01.ane.0000150597.94682.85","title":"Cerebrospinal Fluid and Plasma Pharmacokinetics of the Cyclooxygenase 2 Inhibitor Rofecoxib in Humans: Single and Multiple Oral Drug Administration","year":2005,"lang":"en","type":"article","venue":"Anesthesia & Analgesia","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Rofecoxib; Pharmacokinetics; Cerebrospinal fluid; Medicine; Dosing; Pharmacology; Cyclooxygenase; Area under the curve; Analgesic; Anesthesia; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004187218,0.000393317,0.0007834115,0.0002822154,0.00044215,0.0006501926,0.0001202683,0.0005443471,0.001020633],"category_scores_gemma":[0.001008696,0.000223934,0.000209296,0.0001898522,0.0004698992,0.0003829561,0.0001490747,0.0005457706,0.0002679916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002922734,"about_ca_system_score_gemma":0.0005397527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001028685,"about_ca_topic_score_gemma":0.001010855,"domain_scores_codex":[0.9997255,0.00007968985,0.00002212766,0.00006843029,0.00006934041,0.00003478302],"domain_scores_gemma":[0.999736,0.00006305868,0.00007293709,0.00003134219,0.00003433578,0.00006234364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1024451,0.007203839,0.2856679,0.0007794379,0.001007935,0.004156611,0.001842688,0.002056977,0.3275557,0.0007007004,0.004822586,0.2617606],"study_design_scores_gemma":[0.00251093,0.1072772,0.7550936,0.00008647303,0.0007915957,0.007037916,0.0006615184,0.007347191,0.1000027,0.000763846,0.01830485,0.0001222609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945716,0.00246171,0.001472766,0.00008295765,0.00004567789,0.0001746093,0.0003201719,0.00003784173,0.000832659],"genre_scores_gemma":[0.9968538,0.0007596174,0.0009873917,0.0001470573,0.00006884546,0.0002184414,0.000288579,0.000008970877,0.0006675239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028685,"threshold_uncertainty_score":0.003414392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007141671376719,"score_gpt":0.2434553657654352,"score_spread":0.233383949051668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}