{"id":"W2034104594","doi":"10.1073/pnas.1407358111","title":"( <i>R</i> )-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Methyltransferase; Chemistry; Cell biology; Methylation; Molecular biology; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006619741,0.00006192063,0.0001028792,0.00007902901,0.00003958182,0.000004632593,0.0001622515,0.00009393737,0.000001009829],"category_scores_gemma":[0.0001033129,0.00004744281,0.00004138871,0.0003301426,0.0003485376,0.0000176652,0.00005252106,0.00007252548,6.447555e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001378582,"about_ca_system_score_gemma":0.00002916827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001429977,"about_ca_topic_score_gemma":5.868392e-7,"domain_scores_codex":[0.999206,0.000009785586,0.0001628305,0.0001915538,0.0003492849,0.00008053111],"domain_scores_gemma":[0.9996253,0.00002431505,0.0001746882,0.000006999634,0.0001505602,0.00001815949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003744485,0.00002594539,0.001784273,0.00003273231,0.000008950742,3.217737e-10,0.00009382264,0.0001677391,0.9962785,0.0002716117,0.0001547652,0.00114417],"study_design_scores_gemma":[0.0002115349,0.00009385495,0.03021683,0.00003209523,0.000006971245,0.000001284474,0.00002384145,0.000701212,0.9664102,0.002147417,0.0001068473,0.0000479637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983042,0.0001065012,0.0000102193,0.0008561945,0.00001082332,0.0001231525,0.00001335082,0.000001251879,0.0005743027],"genre_scores_gemma":[0.9994072,0.0000595065,0.0003766717,0.00008239946,0.0000418325,0.000004170559,1.364984e-7,0.000002591341,0.00002547122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0298684,"threshold_uncertainty_score":0.1934662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267208430974956,"score_gpt":0.2654751853355901,"score_spread":0.2528031010258405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}