{"id":"W2034139519","doi":"10.3390/pharmaceutics5030498","title":"Advances in Lipid Nanoparticles for siRNA Delivery","year":2013,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":222,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Alnylam Pharmaceuticals","keywords":"Small interfering RNA; Gene silencing; RNA interference; Drug delivery; RNA; Cytoplasm; Computational biology; Chemistry; Nanotechnology; Cell biology; Gene; Biology; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001120766,0.0007026437,0.0004876019,0.0007706764,0.0003203557,0.0007970421,0.0004219915,0.0009378599,0.001240258],"category_scores_gemma":[0.0005290998,0.0003658483,0.0004585674,0.0004377599,0.0005515487,0.001297412,0.0008159326,0.00155013,0.001483461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008462568,"about_ca_system_score_gemma":0.000786973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000664878,"about_ca_topic_score_gemma":0.0006815474,"domain_scores_codex":[0.9996021,0.00009457175,0.00003164572,0.00008514928,0.0001514825,0.00003503235],"domain_scores_gemma":[0.9997938,0.00007576094,0.00002635793,0.00001606677,0.00007317898,0.00001487056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001255085,0.0001541453,0.0002541062,0.002164017,0.00004965415,0.0006296387,0.0003495407,0.002425917,0.6902573,0.05977925,0.005645049,0.2381659],"study_design_scores_gemma":[0.00004898045,0.0004652865,0.0003572095,0.0003226842,0.00005635868,0.001450484,0.00007652072,0.005316765,0.4882837,0.01276269,0.4907832,0.00007617377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.04027561,0.5937365,0.3022335,0.01037185,0.002564948,0.0003224466,0.0002400704,0.0007745891,0.04948054],"genre_scores_gemma":[0.1899662,0.5630317,0.2130061,0.003350801,0.001246924,0.0005223976,0.0003700805,0.000249471,0.02825638],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001240258,"threshold_uncertainty_score":0.006139994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02593901748402649,"score_gpt":0.3188863563269368,"score_spread":0.2929473388429104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}