{"id":"W2034141079","doi":"10.1016/j.bmc.2007.07.038","title":"Synthesis of chlorogenic acid derivatives with promising antifungal activity","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":false,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada); Memorial University of Newfoundland","funders":"","keywords":"Chemistry; Aspergillus fumigatus; Quinic acid; Moiety; Chlorogenic acid; Cryptococcus neoformans; Stereochemistry; Brine shrimp; Antifungal; Potency; Biochemistry; In vitro; Microbiology; Traditional medicine; Food science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652688,0.0004941214,0.0002900154,0.0002871272,0.000256967,0.0002299739,0.0003920346,0.0003457112,0.00169275],"category_scores_gemma":[0.0001475727,0.0001503787,0.0002721917,0.0003836793,0.0002712304,0.00028105,0.0003002025,0.0004968314,0.0005019691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003041861,"about_ca_system_score_gemma":0.0004630291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009196146,"about_ca_topic_score_gemma":0.001063464,"domain_scores_codex":[0.9999155,0.00001289475,0.000007542054,0.000009712769,0.00001405198,0.0000402812],"domain_scores_gemma":[0.9999114,0.0000110584,0.00001954589,0.00001114556,0.00001505321,0.00003182811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164522,0.0001789842,0.0004048458,0.0005197854,0.00003333394,0.001266658,0.0001609302,0.001793166,0.9679575,0.001758224,0.0005629823,0.02419911],"study_design_scores_gemma":[0.0001314603,0.001182564,0.001403164,0.00001833455,0.00004097493,0.000572759,0.00003641863,0.0005656132,0.9852126,0.0002662698,0.01054126,0.00002869462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.951961,0.01089294,0.01842216,0.0005274691,0.0001695884,0.0002342689,0.001171105,0.0002770196,0.01634459],"genre_scores_gemma":[0.9881418,0.003700797,0.005118769,0.00009664516,0.00002485739,0.00003741531,0.0004152977,0.00002241957,0.00244206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169275,"threshold_uncertainty_score":0.005662799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396811730506298,"score_gpt":0.259377211259244,"score_spread":0.245409093954181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}