{"id":"W2034142957","doi":"10.4161/cc.22604","title":"Predicting PARP inhibitor sensitivity and resistance","year":2012,"lang":"en","type":"letter","venue":"Cell Cycle","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Cancer Foundation; Alberta Bible College","funders":"","keywords":"Biology; PARP inhibitor; Poly ADP ribose polymerase; Sensitivity (control systems); Resistance (ecology); Cell biology; Genetics; DNA; Polymerase; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001366236,0.0004977536,0.00123077,0.000521136,0.0008032285,0.001644148,0.0005357678,0.006576144,0.002533287],"category_scores_gemma":[0.01192928,0.0003347908,0.0004974896,0.000435771,0.0005712123,0.000847324,0.0003970191,0.00679936,0.002555756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001608472,"about_ca_system_score_gemma":0.0009109792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001291905,"about_ca_topic_score_gemma":0.002969139,"domain_scores_codex":[0.9988181,0.000400077,0.000162569,0.0001192482,0.0003543725,0.0001457246],"domain_scores_gemma":[0.9969472,0.001751065,0.0001738849,0.0001056335,0.0007451497,0.0002770462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009742323,0.0003369529,0.03745471,0.0002070507,0.00009291735,0.01137372,0.0002280077,0.0007354469,0.003837256,0.002220244,0.7614321,0.1811074],"study_design_scores_gemma":[0.0009538771,0.001871307,0.05264052,0.0006939934,0.0004198018,0.06594349,0.001079025,0.01329106,0.008545098,0.0180748,0.8363368,0.000150175],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.03322954,0.007419879,0.001444323,0.9122336,0.02100682,0.0001401354,0.0004040631,0.0001338034,0.02398802],"genre_scores_gemma":[0.2507158,0.01113793,0.005928752,0.6265685,0.06662375,0.0003710828,0.0006084529,0.0001002973,0.03794537],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.006576144,"threshold_uncertainty_score":0.01167035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634994991995971,"score_gpt":0.2547407303510907,"score_spread":0.238390780431131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}