{"id":"W2034142957","doi":"10.4161/cc.22604","title":"Predicting PARP inhibitor sensitivity and resistance","year":2012,"lang":"en","type":"letter","venue":"Cell Cycle","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Cancer Foundation; Alberta Bible College","funders":"","keywords":"Biology; PARP inhibitor; Poly ADP ribose polymerase; Sensitivity (control systems); Resistance (ecology); Cell biology; Genetics; DNA; Polymerase; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003011359,0.0002903799,0.0004514254,0.00008655388,0.0001118911,0.00002820219,0.00004345234,0.000599579,0.0001563557],"category_scores_gemma":[0.00003270663,0.0002882897,0.00009890052,0.00009589023,0.0001529989,0.00009288054,0.00004795578,0.001406072,0.0001019624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617518,"about_ca_system_score_gemma":0.00008113553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002756161,"about_ca_topic_score_gemma":0.0000140256,"domain_scores_codex":[0.9983067,0.0001267723,0.0002800906,0.000444463,0.0003764414,0.0004655419],"domain_scores_gemma":[0.998904,0.0002146274,0.0001957,0.0004679766,0.00007863952,0.0001389958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007044846,0.00003590479,0.003467154,0.0008161547,0.00003630466,0.0003930172,0.0002478802,2.830456e-7,0.008804869,0.000003806037,0.9858813,0.0002428863],"study_design_scores_gemma":[0.00117638,0.00004231558,0.00179451,0.0005784857,0.0001326911,0.00009062263,0.00002359276,0.00001862969,0.01818337,0.0000916143,0.9775431,0.0003247201],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.2538144,0.011984,0.0002319735,0.6203024,0.002966834,0.001467044,0.0003354787,0.0005995867,0.1082982],"genre_scores_gemma":[0.3458264,0.000380239,0.001305216,0.6024005,0.02720826,0.00008158149,0.0003170939,0.0002043347,0.0222764],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09201195,"threshold_uncertainty_score":0.9999569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01634994991995971,"score_gpt":0.2547407303510907,"score_spread":0.238390780431131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}