{"id":"W2034169725","doi":"10.1081/ncn-100002476","title":"CHIMERIC RNA WITH MODIFIED BACKBONES: ALTERNATING METHYLENE(METHYLIMINO) LINKED PHOSPHODIESTER BACKBONE OLIGONUCLEOTIDES WITH 2′-OH AND 2′-OMe GROUPS","year":2001,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Science Council; McGill University","keywords":"Phosphodiester bond; Oligonucleotide; Methylene; Chemistry; RNA; Stereochemistry; Medicinal chemistry; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004989263,0.000968711,0.0008369635,0.00025483,0.0006495321,0.0004482095,0.0007552016,0.0003514949,0.0001982522],"category_scores_gemma":[0.00008398119,0.0007917366,0.0002121185,0.0006365734,0.000906414,0.0001306498,0.0003627944,0.0004861645,0.00007076824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009004605,"about_ca_system_score_gemma":0.0001125725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003113129,"about_ca_topic_score_gemma":0.0001702655,"domain_scores_codex":[0.9955818,0.0001804136,0.0008252201,0.001639891,0.000624974,0.001147702],"domain_scores_gemma":[0.9970847,0.00009197744,0.0005138047,0.001457065,0.0003527417,0.0004996542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002942054,0.000743239,0.05515702,0.0002441794,0.00145393,0.0002059692,0.001650702,0.002220195,0.8642815,0.002888774,0.001076058,0.06713638],"study_design_scores_gemma":[0.02236084,0.009657293,0.5488927,0.001613024,0.002052928,0.003137831,0.009361924,0.007647557,0.2524507,0.001876597,0.1307417,0.01020686],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880843,0.002185731,0.002714068,0.0006758511,0.0001773742,0.0007455124,0.00003686855,0.000206964,0.005173356],"genre_scores_gemma":[0.976428,0.002357177,0.01790858,0.001276698,0.0004684678,0.0001426931,0.00008437515,0.0003238313,0.001010136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6118308,"threshold_uncertainty_score":0.9994534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274217709195653,"score_gpt":0.2331806969225984,"score_spread":0.2204385198306419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}