{"id":"W2034169725","doi":"10.1081/ncn-100002476","title":"CHIMERIC RNA WITH MODIFIED BACKBONES: ALTERNATING METHYLENE(METHYLIMINO) LINKED PHOSPHODIESTER BACKBONE OLIGONUCLEOTIDES WITH 2′-OH AND 2′-OMe GROUPS","year":2001,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Science Council; McGill University","keywords":"Phosphodiester bond; Oligonucleotide; Methylene; Chemistry; RNA; Stereochemistry; Medicinal chemistry; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000204519,0.0004084482,0.0002362495,0.00009213691,0.00009649626,0.0002143166,0.0004512474,0.0003398251,0.001114581],"category_scores_gemma":[0.0001492871,0.0002268919,0.000269381,0.0001048447,0.0001859578,0.0001779281,0.0001940882,0.00065176,0.0006255911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544937,"about_ca_system_score_gemma":0.0001435598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000222564,"about_ca_topic_score_gemma":0.0002964988,"domain_scores_codex":[0.9998972,0.00001677171,0.000008080453,0.00003621947,0.00002198788,0.0000197262],"domain_scores_gemma":[0.9998974,0.0000163225,0.00003311624,0.00001502054,0.000009881891,0.00002823822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002965701,0.000006257672,0.0000313963,0.00002043324,0.000003009318,0.00002142925,0.00000711186,0.00007976843,0.9988636,0.0001016961,0.00001306022,0.000822667],"study_design_scores_gemma":[0.00001059688,0.0001441071,0.0003074032,0.000002779774,0.0000137001,0.0001454261,0.000005894117,0.0004979502,0.996559,0.00002579408,0.002282945,0.000004446941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545727,0.001460914,0.03955682,0.0001683092,0.00008787378,0.000126793,0.0003673264,0.0005037562,0.003155586],"genre_scores_gemma":[0.9553727,0.0007129998,0.03819244,0.0001029538,0.00002669063,0.0001127935,0.0007403214,0.00007386011,0.004665362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001114581,"threshold_uncertainty_score":0.003728628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274217709195653,"score_gpt":0.2331806969225984,"score_spread":0.2204385198306419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}