{"id":"W2034178926","doi":"10.1016/s1525-0016(03)00129-1","title":"Expression of dystrophin driven by the 1.35-kb MCK promoter ameliorates muscular dystrophy in fast, but not in slow muscles of transgenic mdx mice","year":2003,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Bundesministerium für Bildung und Forschung; Muscular Dystrophy Association","keywords":"Muscular dystrophy; Dystrophin; Duchenne muscular dystrophy; Transgene; Utrophin; Genetic enhancement; Biology; mdx mouse; Skeletal muscle; Dystrophy; Phenotype; Gene expression; Genetically modified mouse; ITGA7; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916634,0.0006760332,0.0003661544,0.00045712,0.0001288186,0.0001728195,0.0002452939,0.0003379483,0.001041267],"category_scores_gemma":[0.0001070557,0.0002139061,0.0001835324,0.0001287867,0.0003432923,0.0002337112,0.0002393856,0.0005637014,0.0003061181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474565,"about_ca_system_score_gemma":0.0002286438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007897414,"about_ca_topic_score_gemma":0.001387084,"domain_scores_codex":[0.9998405,0.00002652428,0.00002493175,0.00003748471,0.00003900054,0.00003154447],"domain_scores_gemma":[0.9998411,0.00002092633,0.00006365935,0.00001060382,0.00001198345,0.00005161476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006153355,0.00002169463,0.0000540567,0.00002351869,0.000002594684,0.00003150362,0.000008003823,0.00003734523,0.9992247,0.00003387262,0.00001620008,0.0004849164],"study_design_scores_gemma":[0.00004754214,0.000752889,0.004616662,0.00002039387,0.00003529347,0.000333802,0.00003097969,0.0007416924,0.9907198,0.00006272372,0.002631624,0.000006468311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993509,0.001393853,0.003313167,0.0001289671,0.00003433848,0.00002773626,0.0003713707,0.0001810741,0.0010404],"genre_scores_gemma":[0.9808722,0.00222269,0.004766004,0.0001141075,0.00002689592,0.00007552561,0.0007997608,0.0001425325,0.01098034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001041267,"threshold_uncertainty_score":0.003483355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006931936180471376,"score_gpt":0.2241894869597041,"score_spread":0.2172575507792327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}