{"id":"W2034182297","doi":"10.1006/gyno.2002.6762","title":"A Phase II Study of the MDR Inhibitor Biricodar (INCEL, VX-710) and Paclitaxel in Women with Advanced Ovarian Cancer Refractory to Paclitaxel Therapy","year":2002,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Notre-Dame; Jewish General Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Paclitaxel; Tolerability; Neutropenia; Internal medicine; Gastroenterology; Toxicity; Pharmacokinetics; Febrile neutropenia; Chemotherapy; Ovarian cancer; Refractory (planetary science); Oncology; Urology; Surgery; Pharmacology; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001927999,0.001284056,0.00295064,0.0007709089,0.0007876528,0.001160185,0.001078394,0.00197779,0.003994733],"category_scores_gemma":[0.002121794,0.001182104,0.001424572,0.0008520226,0.001696578,0.001325904,0.0004718092,0.004358838,0.000832135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001251832,"about_ca_system_score_gemma":0.00238478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003237348,"about_ca_topic_score_gemma":0.006337639,"domain_scores_codex":[0.9991888,0.0004337927,0.0000340587,0.000114316,0.00004976421,0.0001791557],"domain_scores_gemma":[0.9985604,0.0003888983,0.0001607658,0.0001379758,0.00005799817,0.0006940132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8598524,0.07027412,0.005864767,0.0003525221,0.000820539,0.0003533298,0.000344451,0.001429392,0.01522131,0.000255314,0.001418573,0.04381328],"study_design_scores_gemma":[0.5511217,0.4358696,0.008105881,0.00001678018,0.0005116215,0.0002327956,0.0001255689,0.0006800979,0.001376968,0.0001691853,0.001763938,0.00002595376],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934368,0.001741016,0.0003821784,0.0006870435,0.0001565061,0.001614906,0.0005368555,0.00005904199,0.00138577],"genre_scores_gemma":[0.9899255,0.002207154,0.001121063,0.0008760994,0.0003068929,0.001811574,0.001330655,0.00003278842,0.002388096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003994733,"threshold_uncertainty_score":0.01336372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473335631819492,"score_gpt":0.3059333738720892,"score_spread":0.2812000175538943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}