{"id":"W2034182297","doi":"10.1006/gyno.2002.6762","title":"A Phase II Study of the MDR Inhibitor Biricodar (INCEL, VX-710) and Paclitaxel in Women with Advanced Ovarian Cancer Refractory to Paclitaxel Therapy","year":2002,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Notre-Dame; Jewish General Hospital; BC Cancer Agency","funders":"","keywords":"Medicine; Paclitaxel; Tolerability; Neutropenia; Internal medicine; Gastroenterology; Toxicity; Pharmacokinetics; Febrile neutropenia; Chemotherapy; Ovarian cancer; Refractory (planetary science); Oncology; Urology; Surgery; Pharmacology; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000461996,0.000289618,0.0008458791,0.0001882506,0.0001665697,0.000006419734,0.0002045182,0.0002351516,0.0005708046],"category_scores_gemma":[0.00009123699,0.0001663583,0.00004911182,0.0006063401,0.0002100218,0.00007635904,0.00007041437,0.0004096292,0.000004910604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004990355,"about_ca_system_score_gemma":0.0002131016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009845993,"about_ca_topic_score_gemma":0.002023375,"domain_scores_codex":[0.9978681,0.0002011369,0.0005262542,0.0005394846,0.00029026,0.000574807],"domain_scores_gemma":[0.9987795,0.000198216,0.0002397477,0.0004631129,0.0001064449,0.0002129507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02188902,0.06934165,0.07124058,0.0002380189,0.000610312,0.001164377,0.07976799,0.00008535458,0.1245229,0.0002091503,0.001779545,0.629151],"study_design_scores_gemma":[0.103893,0.2331198,0.4877112,0.0003038078,0.000217648,0.00004644445,0.03485826,0.00004452021,0.002613685,0.0004464913,0.1359032,0.0008419519],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919178,0.001063779,0.000007888258,0.003087165,0.000391555,0.002364175,0.00002333178,0.00004683488,0.001097457],"genre_scores_gemma":[0.9951416,0.0006454202,0.0004452439,0.00194718,0.0000782435,0.0006703715,0.00000139961,0.00003003539,0.001040471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6283091,"threshold_uncertainty_score":0.6783893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02473335631819492,"score_gpt":0.3059333738720892,"score_spread":0.2812000175538943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}