{"id":"W2034200613","doi":"10.1016/j.bbrc.2009.04.146","title":"In vitro reprogramming of adult hepatocytes into insulin-producing cells without viral vectors","year":2009,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"Japan Society for the Promotion of Science","keywords":"PDX1; Reprogramming; Transfection; Biology; Nucleofection; Cell biology; Pancreas; Viral vector; Transdifferentiation; Somatic cell; Insulin; Islet; Cell; Cell culture; Stem cell; Endocrinology; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004044493,0.0002995718,0.0003120876,0.0002292224,0.0002206295,0.0005004783,0.000244889,0.0002233891,0.002375886],"category_scores_gemma":[0.0002028411,0.0001862275,0.0003957983,0.0002147216,0.0002191211,0.0002042725,0.0002550517,0.0007894664,0.0009595508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001494107,"about_ca_system_score_gemma":0.0001764321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004572765,"about_ca_topic_score_gemma":0.0007630839,"domain_scores_codex":[0.9997016,0.00005802725,0.00005219358,0.00005864143,0.00007622057,0.00005329203],"domain_scores_gemma":[0.9997874,0.00007080337,0.00003018136,0.00005872403,0.00002056757,0.00003228875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001424199,0.00004319655,0.0002273661,0.00004636272,0.000008516263,0.00008552201,0.00006980082,0.00009788431,0.9958189,0.0003983909,0.0001002574,0.002961309],"study_design_scores_gemma":[0.00001102485,0.0001101323,0.0006925976,0.00000385125,0.00001260546,0.0001004481,0.00001492187,0.0003526457,0.9950938,0.0000520079,0.003553249,0.000002770158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9226915,0.001255,0.05469405,0.000178574,0.0005138179,0.00045096,0.002870853,0.0006086868,0.01673664],"genre_scores_gemma":[0.9582248,0.0008238914,0.02280669,0.0001232891,0.00005053434,0.0002155619,0.002553184,0.0002134455,0.01498865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375886,"threshold_uncertainty_score":0.007948101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04376507206660402,"score_gpt":0.3663806409622049,"score_spread":0.3226155688956009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}