{"id":"W2034201571","doi":"10.1128/jb.02333-14","title":"Role of the Streptococcus mutans CRISPR-Cas Systems in Immunity and Cell Physiology","year":2014,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research","keywords":"CRISPR; Biology; Plasmid; Streptococcus mutans; Cas9; Transformation (genetics); Virulence; Heat shock; Transduction (biophysics); Gene; Microbiology; Genetics; Bacteria; Heat shock protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508383,0.0004394278,0.0003334158,0.000330681,0.000233253,0.0006535171,0.0002313659,0.0004514746,0.0005428104],"category_scores_gemma":[0.0001838499,0.0001422482,0.0001996667,0.0001437155,0.0003523249,0.0002607559,0.000397863,0.0003919876,0.0002854006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004929932,"about_ca_system_score_gemma":0.0004127918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008391128,"about_ca_topic_score_gemma":0.0006734405,"domain_scores_codex":[0.9997713,0.00004056403,0.00002171375,0.00005197137,0.00006514668,0.0000493089],"domain_scores_gemma":[0.9998385,0.00002526984,0.00004534837,0.00001848622,0.00002270131,0.00004983908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006993084,0.00001633818,0.0006449896,0.00005182659,0.00000598575,0.0001018482,0.00003064223,0.0001898108,0.9942346,0.0004799999,0.0000427716,0.004131193],"study_design_scores_gemma":[0.0000108979,0.0001889979,0.01851776,0.00002188045,0.00001950718,0.0007446543,0.0001025555,0.00387204,0.970649,0.0005276257,0.005321546,0.0000235044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763131,0.006248644,0.0115762,0.0002800767,0.00004003808,0.00003494429,0.0003208879,0.0003615829,0.004824488],"genre_scores_gemma":[0.9955745,0.0006850027,0.002270497,0.0000281515,0.000004780333,0.0000117184,0.0001465964,0.00001196036,0.001266953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008391128,"threshold_uncertainty_score":0.003576934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00381523081698011,"score_gpt":0.2404047211463443,"score_spread":0.2365894903293642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}