{"id":"W2034201571","doi":"10.1128/jb.02333-14","title":"Role of the Streptococcus mutans CRISPR-Cas Systems in Immunity and Cell Physiology","year":2014,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research","keywords":"CRISPR; Biology; Plasmid; Streptococcus mutans; Cas9; Transformation (genetics); Virulence; Heat shock; Transduction (biophysics); Gene; Microbiology; Genetics; Bacteria; Heat shock protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255379,0.00008760305,0.0002363581,0.00004316388,0.00001958748,0.000004319797,0.0001801374,0.0001261841,0.00000381569],"category_scores_gemma":[0.00008048075,0.00006152556,0.00006088153,0.00004708872,0.00007946337,0.00000235447,0.00009104935,0.0001537264,3.372636e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007034413,"about_ca_system_score_gemma":0.00003311367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003434223,"about_ca_topic_score_gemma":0.00003043235,"domain_scores_codex":[0.9992403,0.0001720968,0.0003266498,0.00009278232,0.00003900956,0.0001291941],"domain_scores_gemma":[0.999444,0.00003192557,0.0002157046,0.00019838,0.00007561971,0.00003434613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004126373,0.0000257315,0.01086558,0.00002535164,0.00001688711,4.022478e-7,0.00008575008,0.0008972469,0.9875042,0.00002371766,0.00002340787,0.0004904693],"study_design_scores_gemma":[0.000626429,0.0005378287,0.5153307,0.00002720168,0.00001684344,0.00009759288,0.0002837382,0.000272837,0.4754715,0.0001030705,0.007143023,0.0000892689],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975677,0.001367489,0.0005845062,0.00004346306,0.0002438213,0.00006866091,0.000004534819,9.268799e-7,0.0001188914],"genre_scores_gemma":[0.9995652,0.0001734377,0.00007200045,0.00002630382,0.0001348924,0.000002040784,0.000001977055,0.000007644986,0.00001648903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5120327,"threshold_uncertainty_score":0.250894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00381523081698011,"score_gpt":0.2404047211463443,"score_spread":0.2365894903293642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}