{"id":"W2034267606","doi":"10.1186/1472-6750-8-5","title":"Generation of functional scFv intrabody to abate the expression of CD147 surface molecule of 293A cells","year":2008,"lang":"en","type":"article","venue":"BMC Biotechnology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; National Center for Genetic Engineering and Biotechnology; Commission on Higher Education; Thailand Research Fund","keywords":"Biology; Recombinant DNA; Antibody; Molecular biology; Monoclonal antibody; Flow cytometry; clone (Java method); Cell biology; Colocalization; Cell; Phage display; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001417488,0.0001083628,0.0001581266,0.0000513416,0.00004274719,0.000001292795,0.0002572759,0.0003064889,0.00002269783],"category_scores_gemma":[0.0001616473,0.00008680981,0.00008169818,0.0001671065,0.0003017303,0.000001871668,0.0001570024,0.00007927196,0.000003749716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000702008,"about_ca_system_score_gemma":0.0001097369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001543658,"about_ca_topic_score_gemma":0.000007246334,"domain_scores_codex":[0.9991182,0.00006765171,0.0002942412,0.0002464496,0.0001400562,0.0001334101],"domain_scores_gemma":[0.9991081,0.00002089669,0.0001877831,0.0005188758,0.0001322483,0.00003206016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001041066,0.00009117574,0.0009986263,0.00002253297,0.00001540445,7.607216e-7,0.00002811421,0.004604565,0.9925582,0.0001889394,0.00130001,0.00008757466],"study_design_scores_gemma":[0.0002715159,0.0002471726,0.0005234181,0.00001229361,0.00001186657,0.00000728693,0.00003416241,0.0001815213,0.9981564,0.0000294484,0.0004430515,0.00008182733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609061,0.0004628858,0.03809374,0.0001167075,0.0001346838,0.0001777793,0.00004796617,0.00001310509,0.00004706228],"genre_scores_gemma":[0.9938652,0.00006652319,0.005833413,0.00004911164,0.00005301528,0.000008749402,0.0000407542,0.00001328444,0.00006996428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03295911,"threshold_uncertainty_score":0.3540001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04013471171782685,"score_gpt":0.2455507739620184,"score_spread":0.2054160622441916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}