{"id":"W2034267913","doi":"10.1159/000167698","title":"Hypothalamic Preproghrelin Gene Expression Is Repressed by Insulin via Both PI3-K/Akt and ERK1/2 MAPK Pathways in Immortalized, Hypothalamic Neurons","year":2008,"lang":"en","type":"article","venue":"Neuroendocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Endocrinology; Internal medicine; MAPK/ERK pathway; Protein kinase B; Hypothalamus; Insulin; Downregulation and upregulation; PI3K/AKT/mTOR pathway; Gene expression; Gene; Biology; Signal transduction; Cell biology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00003597349,0.0004602927,0.0005618826,0.0003246336,0.0003277088,0.00004247058,0.0005629416,0.0001476094,0.0001596222],"category_scores_gemma":[0.0003058699,0.0004688284,0.000117263,0.0004074115,0.0005105644,0.0003484611,0.0004379844,0.0005953258,0.0001357645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004008386,"about_ca_system_score_gemma":0.00006326025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001059568,"about_ca_topic_score_gemma":0.00001143523,"domain_scores_codex":[0.9957507,0.0004843516,0.0007263396,0.001734039,0.0004046601,0.0008999159],"domain_scores_gemma":[0.9980952,0.000314556,0.0002891877,0.001078123,0.00003694936,0.0001859757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001627961,0.0003562405,0.02536645,0.00002077176,0.000003468858,0.001338216,0.0002057026,0.00005528915,0.9698073,0.00009409734,0.001401956,0.001187715],"study_design_scores_gemma":[0.001990977,0.0002724838,0.1030957,0.0000168724,0.000009662368,0.002098385,0.000008460878,0.0006408237,0.8868639,0.0005983359,0.004069193,0.0003352636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963292,0.000599094,0.00008340833,0.0008734215,0.00034975,0.0006516624,0.00006213889,0.0002583611,0.0007929971],"genre_scores_gemma":[0.991919,0.004697133,0.000291703,0.00212268,0.00006963919,0.00007526486,0.00001569028,0.00007522838,0.0007336153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08294342,"threshold_uncertainty_score":0.9997764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03082678318761614,"score_gpt":0.2412565779629216,"score_spread":0.2104297947753055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}