{"id":"W2034360520","doi":"10.1371/journal.pone.0037251","title":"Computational Predictions of Volatile Anesthetic Interactions with the Microtubule Cytoskeleton: Implications for Side Effects of General Anesthesia","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; Alberta Cancer Foundation; Fundação para a Ciência e a Tecnologia; Ministry of Advanced Education, Government of Alberta","keywords":"Microtubule; Cytoskeleton; Tubulin; Anesthetic; Halothane; Cell biology; Tau protein; Biology; Chemistry; Neuroscience; Biochemistry; Medicine; Alzheimer's disease; Cell; Disease; Pathology; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005493859,0.00008948136,0.0001285876,0.00003166799,0.00009227054,0.000005728764,0.0001080593,0.00004860233,0.000002995445],"category_scores_gemma":[0.00001868608,0.00006912595,0.00006534703,0.00007468581,0.00009789108,0.000006907783,0.00002005659,0.00004715074,0.000001097045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009128383,"about_ca_system_score_gemma":0.00004945648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001254231,"about_ca_topic_score_gemma":0.00001124223,"domain_scores_codex":[0.9994968,0.00002992864,0.000156502,0.0001173622,0.00005921268,0.0001401627],"domain_scores_gemma":[0.9993584,0.00006793126,0.000121459,0.0002346175,0.0001759983,0.00004157364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004408873,0.0009008475,0.007122935,0.0001172362,0.0002208777,6.092595e-8,0.00009409038,0.0004418055,0.989631,0.0006211452,0.0007030548,0.0001028895],"study_design_scores_gemma":[0.0007256736,0.0006140828,0.04289177,0.00008808402,0.0004381241,0.00006716019,0.00004123053,0.001396462,0.9508505,0.0001419627,0.002568094,0.0001767763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790522,0.0002904611,0.01931383,0.0006460847,0.00001224198,0.0005532477,0.00004493162,0.000007504742,0.00007947806],"genre_scores_gemma":[0.9889628,0.00002135312,0.01007141,0.0001255413,0.0001170976,0.0002167441,0.0002342387,0.00001824717,0.000232621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03878039,"threshold_uncertainty_score":0.2818874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116211472433509,"score_gpt":0.2312177955278776,"score_spread":0.2195966482845267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}