{"id":"W2034365623","doi":"10.1038/gim.2013.148","title":"“Is a cure in my sight?” Multi-stakeholder perspectives on phase I choroideremia gene transfer clinical trials","year":2013,"lang":"en","type":"article","venue":"Genetics in Medicine","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Alexandra Hospital; University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; University of Alberta; Ministry of Advanced Education, Government of Alberta","keywords":"Choroideremia; Medicine; Clinical trial; Gene transfer; Harm; Intensive care medicine; Ophthalmology; Psychology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001648225,0.0002657805,0.000548061,0.0001459903,0.00003184885,0.00001553024,0.0002426272,0.0003093552,0.0003026403],"category_scores_gemma":[0.0006714676,0.0002077206,0.0001173283,0.0001742767,0.0002235579,0.000003712629,0.00004871731,0.0003146282,0.0000217409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002386342,"about_ca_system_score_gemma":0.00009296012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004799667,"about_ca_topic_score_gemma":0.00007653617,"domain_scores_codex":[0.9974056,0.000398484,0.0009769552,0.0006313443,0.0002428282,0.0003448002],"domain_scores_gemma":[0.9991938,0.0001044528,0.00008288398,0.000372881,0.00009726459,0.0001486843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009678756,0.001974724,0.1039695,0.00005902622,0.0001801544,0.00003879286,0.007113511,0.0002118596,0.8334938,0.0000884749,0.01070657,0.04119575],"study_design_scores_gemma":[0.1098149,0.009033184,0.4912513,0.0007273913,0.0002462587,0.0000277195,0.02273709,0.004211177,0.313548,0.002560245,0.04307937,0.002763244],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886742,0.005234385,0.001931954,0.002376377,0.0002121982,0.0007821927,0.000008227054,0.000008716111,0.0007716971],"genre_scores_gemma":[0.9882399,0.007638674,0.002029966,0.001279128,0.0003351282,0.00008596929,0.00007754417,0.00002866366,0.0002849695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5199457,"threshold_uncertainty_score":0.8470598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2043004282884719,"score_gpt":0.4479528612251884,"score_spread":0.2436524329367165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}