{"id":"W2034377257","doi":"10.1152/ajplung.00016.2009","title":"Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures","year":2009,"lang":"en","type":"article","venue":"American Journal of Physiology-Lung Cellular and Molecular Physiology","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Cystic Fibrosis Foundation Therapeutics; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Apical membrane; Endocytosis; Cell biology; Endocytic cycle; Apical cell; Endosome; Endoplasmic reticulum; Intracellular; Dynamin; Chemistry; Internalization; Transmembrane protein; Epithelial polarity; Biology; Biochemistry; Cell; Receptor; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002623342,0.0001769822,0.0009985954,0.0001939295,0.00003309394,0.000002988477,0.000112645,0.0000721957,0.00001052644],"category_scores_gemma":[0.0001479856,0.0001395717,0.0001541311,0.0001963221,0.001015773,0.00007047303,0.0000491229,0.0003405008,1.232536e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005294427,"about_ca_system_score_gemma":0.00009873301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002715035,"about_ca_topic_score_gemma":0.000001214314,"domain_scores_codex":[0.9982489,0.0003471756,0.000640493,0.0002740149,0.0002171499,0.0002722364],"domain_scores_gemma":[0.9988467,0.0001460442,0.0005002155,0.0002043383,0.0001780673,0.0001246768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00119035,0.0002875923,0.0008223118,0.0001825334,0.00007978164,0.00001672523,0.0003534578,0.0002308726,0.9913203,0.0001449834,0.000003964175,0.005367199],"study_design_scores_gemma":[0.001928271,0.004915314,0.4968093,0.0001514102,0.00008151249,0.00005666403,0.0002711458,0.0005917178,0.4938456,0.001213033,0.00001221114,0.0001238894],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997966,0.001282945,0.0003733778,0.0001043311,0.00003148237,0.000202592,0.000005638668,0.000004846151,0.00002878986],"genre_scores_gemma":[0.9978693,0.0001563018,0.00178966,0.00009220001,0.0000616941,0.000001829172,0.00001681284,0.00001066085,0.000001501772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4974747,"threshold_uncertainty_score":0.5691568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006550864190121727,"score_gpt":0.2799651342847149,"score_spread":0.2734142700945931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}