{"id":"W2034406819","doi":"10.1016/j.bbapap.2015.03.012","title":"Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design","year":2015,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Cancer Institute","keywords":"Biology; Computational biology; Functional divergence; Cyclic nucleotide-binding domain; Architecture domain; Structural similarity; Protein domain; Drug discovery; Genetics; Genome; Gene; Nucleotide; Bioinformatics; Biochemistry; Gene family","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006220437,0.0002000278,0.0004028933,0.0006049296,0.0006813814,0.0008012658,0.0005154135,0.0008216493,0.001112076],"category_scores_gemma":[0.0008918674,0.0002179038,0.0003400795,0.0007214579,0.0007510376,0.0006742059,0.0005433135,0.001324278,0.0003815972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007750947,"about_ca_system_score_gemma":0.0005820828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258047,"about_ca_topic_score_gemma":0.001505559,"domain_scores_codex":[0.9997863,0.00005116469,0.00001506621,0.00005214656,0.00004702727,0.00004833949],"domain_scores_gemma":[0.9992846,0.0002273477,0.0001570038,0.000076729,0.0001182548,0.0001360784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00140788,0.0002781882,0.0412418,0.0002959416,0.0001483108,0.001326839,0.001069177,0.006915698,0.8746566,0.01543464,0.000566576,0.05665836],"study_design_scores_gemma":[0.0003335128,0.001815659,0.644948,0.0003037775,0.0003930461,0.01271413,0.003633434,0.04400254,0.1983366,0.0364029,0.05682169,0.0002946346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923434,0.00179301,0.003068173,0.0004499699,0.00002455252,0.00001102182,0.0001311283,0.00001634724,0.002162341],"genre_scores_gemma":[0.9968209,0.0005821628,0.001709557,0.0002230135,0.00001683587,0.000007856027,0.0002203108,0.00001060847,0.0004086963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258047,"threshold_uncertainty_score":0.005623758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02379466301757007,"score_gpt":0.2521292905613579,"score_spread":0.2283346275437878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}