{"id":"W2034427729","doi":"10.1016/j.molcel.2008.12.004","title":"Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing","year":2008,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Cancer Institute; National Institutes of Health; Dana-Farber/Harvard Cancer Center; McKnight Foundation","keywords":"Translation (biology); Biology; Untranslated region; Psychological repression; Cell biology; Eukaryotic translation; PI3K/AKT/mTOR pathway; Hypoxia (environmental); Protein biosynthesis; Five prime untranslated region; Three prime untranslated region; Messenger RNA; Signal transduction; Genetics; Gene expression; Oxygen; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001572538,0.0002681266,0.0002727732,0.0001237588,0.00009571108,0.00001239964,0.0001751007,0.0001989469,0.00002559081],"category_scores_gemma":[0.00003300102,0.0002981022,0.0002282453,0.0002226769,0.00005543102,0.000004323814,0.0000911607,0.0001152871,0.00002511869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002081939,"about_ca_system_score_gemma":0.0001814678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004596521,"about_ca_topic_score_gemma":0.00004011217,"domain_scores_codex":[0.9983264,0.000118075,0.0003875534,0.0005130139,0.0002674674,0.0003874984],"domain_scores_gemma":[0.9990259,0.000009175485,0.0001325634,0.0004512597,0.0001914762,0.0001896086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001319841,0.00004951393,0.00002076056,0.00003567118,0.00003629567,0.00002094483,0.0003429313,0.000337724,0.9902313,0.00001107059,0.001366906,0.007414837],"study_design_scores_gemma":[0.0008738404,0.0002332884,0.0001500368,0.00001535375,0.00004965919,0.00001510104,0.0000903933,0.00006187725,0.8920877,0.000006115917,0.1061196,0.0002970745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980248,0.007171556,0.008521193,0.0003850106,0.0005370622,0.0005822481,0.00003126502,0.00001978653,0.002503905],"genre_scores_gemma":[0.9924369,0.0006109931,0.004704095,0.0007380353,0.0006713287,0.00001469807,0.0001213648,0.00006456249,0.0006380049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1047526,"threshold_uncertainty_score":0.9999471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01626710250719936,"score_gpt":0.2278735102071587,"score_spread":0.2116064076999593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}